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ST resolution 1 hour after fibrinolysis for prediction of myocardial infarct size: insights from ASSENT 3.

Publication ,  Journal Article
Johanson, P; Fu, Y; Wagner, GS; Goodman, SG; Granger, CB; Wallentin, L; Van de Werf, F; Armstrong, PW; ASSENT 3 Investigators,
Published in: Am J Cardiol
January 15, 2009

Acute ST-segment elevation myocardial infarction requires prompt restoration of myocardial perfusion to salvage myocardium at risk of ischemic necrosis and improve clinical outcome. Early resolution of ST-segment elevation during the time after reperfusion has been associated with both these end points. From the ASsessment of the Safety and Efficacy of a New Thrombolytic regimen (ASSENT) 3 trial, 3,425 patients were analyzed to investigate whether the amount of ST-segment resolution, divided into 3 groups (complete, >70%; partial, 30% to 70%; and no resolution, <30%), in the first hour after initiation of therapy was a predictor of final infarct size, estimated by peak creatine kinase and Selvester QRS score on the discharge electrocardiogram. Complete compared with partial and no ST resolution resulted in significantly (p<0.001) smaller infarct sizes of 10.5%, 13.2%, and 15.0% of the left ventricle and significantly (p=0.001) fewer patients with peak creatine >5 times the upper reference level at 50.3%, 71.8%, and 76.3%, respectively. In conclusion, our findings supported previous smaller studies suggesting that early resolution of ST elevation, as a sign of early myocardial reperfusion, resulted in less myocardial damage and preservation of left ventricular function.

Duke Scholars

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

January 15, 2009

Volume

103

Issue

2

Start / End Page

154 / 158

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Thrombolytic Therapy
  • Risk Factors
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
  • Fibrinolytic Agents
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Johanson, P., Fu, Y., Wagner, G. S., Goodman, S. G., Granger, C. B., Wallentin, L., … ASSENT 3 Investigators, . (2009). ST resolution 1 hour after fibrinolysis for prediction of myocardial infarct size: insights from ASSENT 3. Am J Cardiol, 103(2), 154–158. https://doi.org/10.1016/j.amjcard.2008.08.054
Johanson, Per, Yuling Fu, Galen S. Wagner, Shaun G. Goodman, Chris B. Granger, Lars Wallentin, Frans Van de Werf, Paul W. Armstrong, and Paul W. ASSENT 3 Investigators. “ST resolution 1 hour after fibrinolysis for prediction of myocardial infarct size: insights from ASSENT 3.Am J Cardiol 103, no. 2 (January 15, 2009): 154–58. https://doi.org/10.1016/j.amjcard.2008.08.054.
Johanson P, Fu Y, Wagner GS, Goodman SG, Granger CB, Wallentin L, et al. ST resolution 1 hour after fibrinolysis for prediction of myocardial infarct size: insights from ASSENT 3. Am J Cardiol. 2009 Jan 15;103(2):154–8.
Johanson, Per, et al. “ST resolution 1 hour after fibrinolysis for prediction of myocardial infarct size: insights from ASSENT 3.Am J Cardiol, vol. 103, no. 2, Jan. 2009, pp. 154–58. Pubmed, doi:10.1016/j.amjcard.2008.08.054.
Johanson P, Fu Y, Wagner GS, Goodman SG, Granger CB, Wallentin L, Van de Werf F, Armstrong PW, ASSENT 3 Investigators. ST resolution 1 hour after fibrinolysis for prediction of myocardial infarct size: insights from ASSENT 3. Am J Cardiol. 2009 Jan 15;103(2):154–158.
Journal cover image

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

January 15, 2009

Volume

103

Issue

2

Start / End Page

154 / 158

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Thrombolytic Therapy
  • Risk Factors
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
  • Fibrinolytic Agents
  • Female