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The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm.

Publication ,  Journal Article
Helgadottir, A; Thorleifsson, G; Magnusson, KP; Grétarsdottir, S; Steinthorsdottir, V; Manolescu, A; Jones, GT; Rinkel, GJE; Blankensteijn, JD ...
Published in: Nat Genet
February 2008
Published version (DOI) Link to item

Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD) and type 2 diabetes (T2D), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) = 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined. These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases.

Duke Scholars

Svati Hasmukh Shah
Author Svati Hasmukh Shah Medicine, Cardiology
Christopher Bull Granger
Author Christopher Bull Granger Medicine, Cardiology
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Published In

Nat Genet

DOI

10.1038/ng.72

EISSN

1546-1718

Publication Date

February 2008

Volume

40

Issue

2

Start / End Page

217 / 224

Location

United States

Related Subject Headings

  • White People
  • Sequence Analysis, DNA
  • Risk Factors
  • Probability
  • Prevalence
  • Polymorphism, Single Nucleotide
  • Odds Ratio
  • Myocardial Infarction
  • Middle Aged
  • Male
 

Citation

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Helgadottir, A., Thorleifsson, G., Magnusson, K. P., Grétarsdottir, S., Steinthorsdottir, V., Manolescu, A., … Stefansson, K. (2008). The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet, 40(2), 217–224. https://doi.org/10.1038/ng.72
Helgadottir, Anna, Gudmar Thorleifsson, Kristinn P. Magnusson, Solveig Grétarsdottir, Valgerdur Steinthorsdottir, Andrei Manolescu, Gregory T. Jones, et al. “The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm.” Nat Genet 40, no. 2 (February 2008): 217–24. https://doi.org/10.1038/ng.72.
Helgadottir A, Thorleifsson G, Magnusson KP, Grétarsdottir S, Steinthorsdottir V, Manolescu A, et al. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet. 2008 Feb;40(2):217–24.
Helgadottir, Anna, et al. “The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm.” Nat Genet, vol. 40, no. 2, Feb. 2008, pp. 217–24. Pubmed, doi:10.1038/ng.72.
Helgadottir A, Thorleifsson G, Magnusson KP, Grétarsdottir S, Steinthorsdottir V, Manolescu A, Jones GT, Rinkel GJE, Blankensteijn JD, Ronkainen A, Jääskeläinen JE, Kyo Y, Lenk GM, Sakalihasan N, Kostulas K, Gottsäter A, Flex A, Stefansson H, Hansen T, Andersen G, Weinsheimer S, Borch-Johnsen K, Jorgensen T, Shah SH, Quyyumi AA, Granger CB, Reilly MP, Austin H, Levey AI, Vaccarino V, Palsdottir E, Walters GB, Jonsdottir T, Snorradottir S, Magnusdottir D, Gudmundsson G, Ferrell RE, Sveinbjornsdottir S, Hernesniemi J, Niemelä M, Limet R, Andersen K, Sigurdsson G, Benediktsson R, Verhoeven ELG, Teijink JAW, Grobbee DE, Rader DJ, Collier DA, Pedersen O, Pola R, Hillert J, Lindblad B, Valdimarsson EM, Magnadottir HB, Wijmenga C, Tromp G, Baas AF, Ruigrok YM, van Rij AM, Kuivaniemi H, Powell JT, Matthiasson SE, Gulcher JR, Thorgeirsson G, Kong A, Thorsteinsdottir U, Stefansson K. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet. 2008 Feb;40(2):217–224.

Published In

Nat Genet

DOI

10.1038/ng.72

EISSN

1546-1718

Publication Date

February 2008

Volume

40

Issue

2

Start / End Page

217 / 224

Location

United States

Related Subject Headings

  • White People
  • Sequence Analysis, DNA
  • Risk Factors
  • Probability
  • Prevalence
  • Polymorphism, Single Nucleotide
  • Odds Ratio
  • Myocardial Infarction
  • Middle Aged
  • Male