Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.
Publication
, Journal Article
Onyewu, C; Eads, E; Schell, WA; Perfect, JR; Ullmann, Y; Kaufman, G; Horwitz, BA; Berdicevsky, I; Heitman, J
Published in: Antimicrob Agents Chemother
October 2007
Fluconazole-FK506 or fluconazole-cyclosporine drug combinations were tested in an ex vivo Trichophyton mentagrophytes human skin infection model. Conidia colonization was monitored by scanning electron microscopy over a 7-day treatment period. The fluconazole-FK506 combination demonstrated the most obvious advantage over single-drug therapy by clearing conidia and protecting skin from damage at low drug concentrations.
Duke Scholars
Published In
Antimicrob Agents Chemother
DOI
ISSN
0066-4804
Publication Date
October 2007
Volume
51
Issue
10
Start / End Page
3743 / 3746
Location
United States
Related Subject Headings
- Trichophyton
- Tinea
- Terbinafine
- Tacrolimus
- Skin
- Signal Transduction
- Naphthalenes
- Microbiology
- Immunosuppressive Agents
- Humans
Citation
APA
Chicago
ICMJE
MLA
NLM
Onyewu, C., Eads, E., Schell, W. A., Perfect, J. R., Ullmann, Y., Kaufman, G., … Heitman, J. (2007). Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model. Antimicrob Agents Chemother, 51(10), 3743–3746. https://doi.org/10.1128/AAC.00492-07
Onyewu, Chiatogu, Emily Eads, Wiley A. Schell, John R. Perfect, Yehuda Ullmann, Gil Kaufman, Benjamin A. Horwitz, Israela Berdicevsky, and Joseph Heitman. “Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.” Antimicrob Agents Chemother 51, no. 10 (October 2007): 3743–46. https://doi.org/10.1128/AAC.00492-07.
Onyewu C, Eads E, Schell WA, Perfect JR, Ullmann Y, Kaufman G, et al. Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model. Antimicrob Agents Chemother. 2007 Oct;51(10):3743–6.
Onyewu, Chiatogu, et al. “Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.” Antimicrob Agents Chemother, vol. 51, no. 10, Oct. 2007, pp. 3743–46. Pubmed, doi:10.1128/AAC.00492-07.
Onyewu C, Eads E, Schell WA, Perfect JR, Ullmann Y, Kaufman G, Horwitz BA, Berdicevsky I, Heitman J. Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model. Antimicrob Agents Chemother. 2007 Oct;51(10):3743–3746.
Published In
Antimicrob Agents Chemother
DOI
ISSN
0066-4804
Publication Date
October 2007
Volume
51
Issue
10
Start / End Page
3743 / 3746
Location
United States
Related Subject Headings
- Trichophyton
- Tinea
- Terbinafine
- Tacrolimus
- Skin
- Signal Transduction
- Naphthalenes
- Microbiology
- Immunosuppressive Agents
- Humans