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Histamine H(1) antagonist treatment with pyrilamine reduces nicotine self-administration in rats.

Publication ,  Journal Article
Levin, ED; Slade, S; Wells, C; Pruitt, M; Cousins, V; Cauley, M; Petro, A; Hampton, D; Rose, J
Published in: Eur J Pharmacol
January 10, 2011

Nicotine has been definitively shown to be critically involved in the neural bases of tobacco addiction. However, nicotine releases a wide variety of neurotransmitters. Nicotine-induced dopamine release has been shown to play a key role in facilitating nicotine self-administration. Other transmitter systems may also play important roles in the pharmacological effects of nicotine and may provide important leads for combating nicotine self-administration. Clozapine, an antipsychotic drug, which blocks a variety of different transmitter receptors including serotonin 5HT(2) and histamine H(1) receptors, has been found to decrease smoking. Previously we found that the serotonin 5HT(2) antagonist, ketanserin, significantly reduced nicotine self-administration. In the current study, we assessed histamine H(1) receptor interaction with nicotine self-administration. Young adult female Sprague-Dawley rats were fitted with IV catheters and trained to self-administer nicotine (0.03mg/kg/infusion). Acute doses of 40mg/kg of pyrilamine, a histamine H(1) antagonist, significantly reduced nicotine self-administration. We also found that repeated injections (20mg/kg) or chronic infusion via osmotic minipumps (50mg/kg/day) of pyrilamine also significantly decreased nicotine self-administration. The peripherally restricted H(1) antagonist ebastine was ineffective in reducing nicotine self-administration, pointing to central H(1) receptor blockade as key for the effectiveness of pyrilamine. H(1) antagonists may be a promising avenue to explore for new treatments to aid smoking cessation.

Duke Scholars

Published In

Eur J Pharmacol

DOI

EISSN

1879-0712

Publication Date

January 10, 2011

Volume

650

Issue

1

Start / End Page

256 / 260

Location

Netherlands

Related Subject Headings

  • Tobacco Use Disorder
  • Self Administration
  • Rats, Sprague-Dawley
  • Rats
  • Pyrilamine
  • Piperidines
  • Pharmacology & Pharmacy
  • Nicotine
  • Motivation
  • Injections
 

Citation

APA
Chicago
ICMJE
MLA
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Levin, E. D., Slade, S., Wells, C., Pruitt, M., Cousins, V., Cauley, M., … Rose, J. (2011). Histamine H(1) antagonist treatment with pyrilamine reduces nicotine self-administration in rats. Eur J Pharmacol, 650(1), 256–260. https://doi.org/10.1016/j.ejphar.2010.10.013
Levin, Edward D., Susan Slade, Corinne Wells, Margaret Pruitt, Vanessa Cousins, Marty Cauley, Ann Petro, Dawn Hampton, and Jed Rose. “Histamine H(1) antagonist treatment with pyrilamine reduces nicotine self-administration in rats.Eur J Pharmacol 650, no. 1 (January 10, 2011): 256–60. https://doi.org/10.1016/j.ejphar.2010.10.013.
Levin ED, Slade S, Wells C, Pruitt M, Cousins V, Cauley M, et al. Histamine H(1) antagonist treatment with pyrilamine reduces nicotine self-administration in rats. Eur J Pharmacol. 2011 Jan 10;650(1):256–60.
Levin, Edward D., et al. “Histamine H(1) antagonist treatment with pyrilamine reduces nicotine self-administration in rats.Eur J Pharmacol, vol. 650, no. 1, Jan. 2011, pp. 256–60. Pubmed, doi:10.1016/j.ejphar.2010.10.013.
Levin ED, Slade S, Wells C, Pruitt M, Cousins V, Cauley M, Petro A, Hampton D, Rose J. Histamine H(1) antagonist treatment with pyrilamine reduces nicotine self-administration in rats. Eur J Pharmacol. 2011 Jan 10;650(1):256–260.
Journal cover image

Published In

Eur J Pharmacol

DOI

EISSN

1879-0712

Publication Date

January 10, 2011

Volume

650

Issue

1

Start / End Page

256 / 260

Location

Netherlands

Related Subject Headings

  • Tobacco Use Disorder
  • Self Administration
  • Rats, Sprague-Dawley
  • Rats
  • Pyrilamine
  • Piperidines
  • Pharmacology & Pharmacy
  • Nicotine
  • Motivation
  • Injections