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Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: relationship to blood ciguatoxin concentrations.

Publication ,  Journal Article
Bottein Dechraoui, M-Y; Rezvani, AH; Gordon, CJ; Levin, ED; Ramsdell, JS
Published in: Toxicology
April 3, 2008

Ciguatera is a common illness in tropical and subtropical regions that manifests in complex and long-lived symptoms which are more severe in subsequent exposures. This study measures central and peripheral neurologic signs, in parallel with blood toxin levels, in mice exposed once or twice (at 3 days interval) to a sublethal dose of ciguatoxin P-CTX-1 (0.26ng/g via i.p.). Mice were implanted with radiotransmitters to monitor motor activity and core temperature. A single exposure to ciguatoxin elicited an immediate and transient decrease in motor activity and temperature, and subsequent long-lasting thermoregulatory dysfunction resulting in stabilized body temperature around 36.0 degrees C with no observable circadian rhythm. The hypothermic response and the reduced activity were enhanced with a second exposure with 30% of the mice dying within 7h. Measurement of the peripheral nervous system by the tail flick assay revealed increased latency with a single ciguatoxin exposure, and a greater effect following the second exposure. Toxin was measurable in blood up to 3 days following the first exposure; at the 1h time point the concentrations were significantly elevated after a second exposure. These findings indicate an early response to ciguatoxin manifest in a central response to lower body temperature and reduce motor activity and a more persistent effect on the peripheral system leading to spinal heat antinociception and delayed fever-like response. The greater neurological response to a second ciguatoxin exposure was associated with elevated concentrations of ciguatoxin in the blood solely over the first hour of exposure. In conclusion, a single exposure to toxin exerts a significant neurological response which may be enhanced with subsequent exposure.

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Published In

Toxicology

DOI

ISSN

0300-483X

Publication Date

April 3, 2008

Volume

246

Issue

1

Start / End Page

55 / 62

Location

Ireland

Related Subject Headings

  • Toxicology
  • Poisons
  • Pain Measurement
  • Motor Activity
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Ciguatoxins
  • Cell Survival
  • Body Weight
 

Citation

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ICMJE
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Bottein Dechraoui, M.-Y., Rezvani, A. H., Gordon, C. J., Levin, E. D., & Ramsdell, J. S. (2008). Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: relationship to blood ciguatoxin concentrations. Toxicology, 246(1), 55–62. https://doi.org/10.1016/j.tox.2007.12.013
Bottein Dechraoui, Marie-Yasmine, Amir H. Rezvani, Christopher J. Gordon, Edward D. Levin, and John S. Ramsdell. “Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: relationship to blood ciguatoxin concentrations.Toxicology 246, no. 1 (April 3, 2008): 55–62. https://doi.org/10.1016/j.tox.2007.12.013.
Bottein Dechraoui, Marie-Yasmine, et al. “Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: relationship to blood ciguatoxin concentrations.Toxicology, vol. 246, no. 1, Apr. 2008, pp. 55–62. Pubmed, doi:10.1016/j.tox.2007.12.013.
Journal cover image

Published In

Toxicology

DOI

ISSN

0300-483X

Publication Date

April 3, 2008

Volume

246

Issue

1

Start / End Page

55 / 62

Location

Ireland

Related Subject Headings

  • Toxicology
  • Poisons
  • Pain Measurement
  • Motor Activity
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Ciguatoxins
  • Cell Survival
  • Body Weight