Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.
Publication
, Journal Article
Del Poeta, M; Schell, WA; Dykstra, CC; Jones, S; Tidwell, RR; Czarny, A; Bajic, M; Kumar, A; Boykin, D; Perfect, JR
Published in: Antimicrob Agents Chemother
October 1998
Twenty analogues of pentamidine, 7 primary metabolites of pentamidine, and 30 dicationic substituted bis-benzimidazoles were screened for their inhibitory and fungicidal activities against Candida albicans and Cryptococcus neoformans. A majority of the compounds had MICs at which 80% of the strains were inhibited (MIC80s) comparable to those of amphotericin B and fluconazole. Unlike fluconazole, many of these compounds were found to have potent fungicidal activity. The most potent compound against C. albicans had an MIC80 of
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Published In
Antimicrob Agents Chemother
DOI
ISSN
0066-4804
Publication Date
October 1998
Volume
42
Issue
10
Start / End Page
2495 / 2502
Location
United States
Related Subject Headings
- Structure-Activity Relationship
- Pentamidine
- Microbiology
- Microbial Sensitivity Tests
- Benzimidazoles
- Antifungal Agents
- 3214 Pharmacology and pharmaceutical sciences
- 3207 Medical microbiology
- 3107 Microbiology
- 1115 Pharmacology and Pharmaceutical Sciences
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Del Poeta, M., Schell, W. A., Dykstra, C. C., Jones, S., Tidwell, R. R., Czarny, A., … Perfect, J. R. (1998). Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents. Antimicrob Agents Chemother, 42(10), 2495–2502. https://doi.org/10.1128/AAC.42.10.2495
Del Poeta, M., W. A. Schell, C. C. Dykstra, S. Jones, R. R. Tidwell, A. Czarny, M. Bajic, A. Kumar, D. Boykin, and J. R. Perfect. “Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.” Antimicrob Agents Chemother 42, no. 10 (October 1998): 2495–2502. https://doi.org/10.1128/AAC.42.10.2495.
Del Poeta M, Schell WA, Dykstra CC, Jones S, Tidwell RR, Czarny A, et al. Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents. Antimicrob Agents Chemother. 1998 Oct;42(10):2495–502.
Del Poeta, M., et al. “Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.” Antimicrob Agents Chemother, vol. 42, no. 10, Oct. 1998, pp. 2495–502. Pubmed, doi:10.1128/AAC.42.10.2495.
Del Poeta M, Schell WA, Dykstra CC, Jones S, Tidwell RR, Czarny A, Bajic M, Kumar A, Boykin D, Perfect JR. Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents. Antimicrob Agents Chemother. 1998 Oct;42(10):2495–2502.
Published In
Antimicrob Agents Chemother
DOI
ISSN
0066-4804
Publication Date
October 1998
Volume
42
Issue
10
Start / End Page
2495 / 2502
Location
United States
Related Subject Headings
- Structure-Activity Relationship
- Pentamidine
- Microbiology
- Microbial Sensitivity Tests
- Benzimidazoles
- Antifungal Agents
- 3214 Pharmacology and pharmaceutical sciences
- 3207 Medical microbiology
- 3107 Microbiology
- 1115 Pharmacology and Pharmaceutical Sciences