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Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore.

Publication ,  Journal Article
Stiber, JA; Seth, M; Rosenberg, PB
Published in: J Cardiovasc Pharmacol
August 2009

Stretch-activated or mechanosensitive channels transduce mechanical forces into ion fluxes across the cell membrane. These channels have been implicated in several aspects of cardiovascular physiology including regulation of blood pressure, vasoreactivity, and cardiac arrhythmias, as well as the adverse remodeling associated with cardiac hypertrophy and heart failure. This review discusses mechanosensitive channels in skeletal muscle and the cardiovascular system and their role in disease pathogenesis. We describe the regulation of gating of mechanosensitive channels including direct mechanisms and indirect activation by signaling pathways, as well as the influence on activation of these channels by the underlying cytoskeleton and scaffolding proteins. We then focus on the role of transient receptor potential channels, several of which have been implicated as mechanosensitive channels, in the pathogenesis of adverse cardiac remodeling and as potential therapeutic targets in the treatment of heart failure.

Duke Scholars

Published In

J Cardiovasc Pharmacol

DOI

EISSN

1533-4023

Publication Date

August 2009

Volume

54

Issue

2

Start / End Page

116 / 122

Location

United States

Related Subject Headings

  • Transient Receptor Potential Channels
  • Signal Transduction
  • Muscle, Skeletal
  • Ion Channels
  • Humans
  • Heart Failure
  • Drug Delivery Systems
  • Cytoskeleton
  • Cardiovascular System & Hematology
  • Cardiovascular System
 

Citation

APA
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ICMJE
MLA
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Stiber, J. A., Seth, M., & Rosenberg, P. B. (2009). Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore. J Cardiovasc Pharmacol, 54(2), 116–122. https://doi.org/10.1097/FJC.0b013e3181aa233f
Stiber, Jonathan A., Malini Seth, and Paul B. Rosenberg. “Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore.J Cardiovasc Pharmacol 54, no. 2 (August 2009): 116–22. https://doi.org/10.1097/FJC.0b013e3181aa233f.
Stiber JA, Seth M, Rosenberg PB. Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore. J Cardiovasc Pharmacol. 2009 Aug;54(2):116–22.
Stiber, Jonathan A., et al. “Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore.J Cardiovasc Pharmacol, vol. 54, no. 2, Aug. 2009, pp. 116–22. Pubmed, doi:10.1097/FJC.0b013e3181aa233f.
Stiber JA, Seth M, Rosenberg PB. Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore. J Cardiovasc Pharmacol. 2009 Aug;54(2):116–122.

Published In

J Cardiovasc Pharmacol

DOI

EISSN

1533-4023

Publication Date

August 2009

Volume

54

Issue

2

Start / End Page

116 / 122

Location

United States

Related Subject Headings

  • Transient Receptor Potential Channels
  • Signal Transduction
  • Muscle, Skeletal
  • Ion Channels
  • Humans
  • Heart Failure
  • Drug Delivery Systems
  • Cytoskeleton
  • Cardiovascular System & Hematology
  • Cardiovascular System