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A tale of two sites: How ubiquitination of a G protein-coupled receptor is coupled to its lysosomal trafficking from distinct receptor domains.

Publication ,  Journal Article
Sarker, S; Xiao, K; Shenoy, SK
Published in: Commun Integr Biol
September 2011

The β(2)-adrenergic receptor (β(2)AR) is a prototypical G(s)-coupled receptor belonging to the superfamily of seven transmembrane spanning heptahelical receptors (7TMRs or G protein-coupled receptors [GPCRs])-therapeutically the most diverse and accessible class of cell surface receptors. The classic pathway of β(2)AR signaling (Fig. 1) is triggered by activation of the heterotrimeric G protein G(s) by agonists (catecholamines-noradrenaline and adrenaline). This in turn activates adenylyl cyclase leading to the generation of second messenger signaling molecules (cyclic adenosine monophosphates, cAMP) which subsequently activate protein kinase A (PKA) as well as some ion channels, such as the class C type of L-type calcium channels, Ca(v)1.2.31 Here in we review how trafficking and signaling of the β(2)AR is regulated by the post-translational modification, ubiquitination.1.

Duke Scholars

Published In

Commun Integr Biol

DOI

EISSN

1942-0889

Publication Date

September 2011

Volume

4

Issue

5

Start / End Page

528 / 531

Location

United States

Related Subject Headings

  • Developmental Biology
  • 3102 Bioinformatics and computational biology
  • 0603 Evolutionary Biology
  • 0601 Biochemistry and Cell Biology
 

Citation

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Sarker, S., Xiao, K., & Shenoy, S. K. (2011). A tale of two sites: How ubiquitination of a G protein-coupled receptor is coupled to its lysosomal trafficking from distinct receptor domains. Commun Integr Biol, 4(5), 528–531. https://doi.org/10.4161/cib.4.5.16458
Sarker, Subhodeep, Kunhong Xiao, and Sudha K. Shenoy. “A tale of two sites: How ubiquitination of a G protein-coupled receptor is coupled to its lysosomal trafficking from distinct receptor domains.Commun Integr Biol 4, no. 5 (September 2011): 528–31. https://doi.org/10.4161/cib.4.5.16458.
Sarker, Subhodeep, et al. “A tale of two sites: How ubiquitination of a G protein-coupled receptor is coupled to its lysosomal trafficking from distinct receptor domains.Commun Integr Biol, vol. 4, no. 5, Sept. 2011, pp. 528–31. Pubmed, doi:10.4161/cib.4.5.16458.

Published In

Commun Integr Biol

DOI

EISSN

1942-0889

Publication Date

September 2011

Volume

4

Issue

5

Start / End Page

528 / 531

Location

United States

Related Subject Headings

  • Developmental Biology
  • 3102 Bioinformatics and computational biology
  • 0603 Evolutionary Biology
  • 0601 Biochemistry and Cell Biology