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Genes, environments, and developmental research: methods for a multi-site study of early substance abuse.

Publication ,  Journal Article
Costello, EJ; Eaves, L; Sullivan, P; Kennedy, M; Conway, K; Adkins, DE; Angold, A; Clark, SL; Erkanli, A; McClay, JL; Copeland, W; Maes, HH ...
Published in: Twin Res Hum Genet
April 2013

The importance of including developmental and environmental measures in genetic studies of human pathology is widely acknowledged, but few empirical studies have been published. Barriers include the need for longitudinal studies that cover relevant developmental stages and for samples large enough to deal with the challenge of testing gene-environment-development interaction. A solution to some of these problems is to bring together existing data sets that have the necessary characteristics. As part of the National Institute on Drug Abuse-funded Gene-Environment-Development Initiative, our goal is to identify exactly which genes, which environments, and which developmental transitions together predict the development of drug use and misuse. Four data sets were used of which common characteristics include (1) general population samples, including males and females; (2) repeated measures across adolescence and young adulthood; (3) assessment of nicotine, alcohol, and cannabis use and addiction; (4) measures of family and environmental risk; and (5) consent for genotyping DNA from blood or saliva. After quality controls, 2,962 individuals provided over 15,000 total observations. In the first gene-environment analyses, of alcohol misuse and stressful life events, some significant gene-environment and gene-development effects were identified. We conclude that in some circumstances, already collected data sets can be combined for gene-environment and gene-development analyses. This greatly reduces the cost and time needed for this type of research. However, care must be taken to ensure careful matching across studies and variables.

Duke Scholars

Published In

Twin Res Hum Genet

DOI

ISSN

1832-4274

Publication Date

April 2013

Volume

16

Issue

2

Start / End Page

505 / 515

Location

England

Related Subject Headings

  • Young Adult
  • United States
  • Twins, Monozygotic
  • Twins, Dizygotic
  • Substance-Related Disorders
  • Social Environment
  • Risk Factors
  • Male
  • Longitudinal Studies
  • Life Change Events
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Costello, E. J., Eaves, L., Sullivan, P., Kennedy, M., Conway, K., Adkins, D. E., … van den Oord, E. (2013). Genes, environments, and developmental research: methods for a multi-site study of early substance abuse. Twin Res Hum Genet, 16(2), 505–515. https://doi.org/10.1017/thg.2013.6
Costello, E Jane, Lindon Eaves, Patrick Sullivan, Martin Kennedy, Kevin Conway, Daniel E. Adkins, A. Angold, et al. “Genes, environments, and developmental research: methods for a multi-site study of early substance abuse.Twin Res Hum Genet 16, no. 2 (April 2013): 505–15. https://doi.org/10.1017/thg.2013.6.
Costello EJ, Eaves L, Sullivan P, Kennedy M, Conway K, Adkins DE, et al. Genes, environments, and developmental research: methods for a multi-site study of early substance abuse. Twin Res Hum Genet. 2013 Apr;16(2):505–15.
Costello, E. Jane, et al. “Genes, environments, and developmental research: methods for a multi-site study of early substance abuse.Twin Res Hum Genet, vol. 16, no. 2, Apr. 2013, pp. 505–15. Pubmed, doi:10.1017/thg.2013.6.
Costello EJ, Eaves L, Sullivan P, Kennedy M, Conway K, Adkins DE, Angold A, Clark SL, Erkanli A, McClay JL, Copeland W, Maes HH, Liu Y, Patkar AA, Silberg J, van den Oord E. Genes, environments, and developmental research: methods for a multi-site study of early substance abuse. Twin Res Hum Genet. 2013 Apr;16(2):505–515.
Journal cover image

Published In

Twin Res Hum Genet

DOI

ISSN

1832-4274

Publication Date

April 2013

Volume

16

Issue

2

Start / End Page

505 / 515

Location

England

Related Subject Headings

  • Young Adult
  • United States
  • Twins, Monozygotic
  • Twins, Dizygotic
  • Substance-Related Disorders
  • Social Environment
  • Risk Factors
  • Male
  • Longitudinal Studies
  • Life Change Events