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Biomarkers for smoking cessation.

Publication ,  Journal Article
Bough, KJ; Lerman, C; Rose, JE; McClernon, FJ; Kenny, PJ; Tyndale, RF; David, SP; Stein, EA; Uhl, GR; Conti, DV; Green, C; Amur, S
Published in: Clin Pharmacol Ther
June 2013

One way to enhance therapeutic development is through the identification and development of evaluative tools such as biomarkers. This review focuses on putative diagnostic, pharmacodynamic, and predictive biomarkers for smoking cessation. These types of biomarkers may be used to more accurately diagnose a disease, personalize treatment, identify novel targets for drug discovery, and enhance the efficiency of drug development. Promising biomarkers are presented across a range of approaches including metabolism, genetics, and neuroimaging. A preclinical viewpoint is also offered, as are analytical considerations and a regulatory perspective summarizing a pathway toward biomarker qualification.

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Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

June 2013

Volume

93

Issue

6

Start / End Page

526 / 538

Location

United States

Related Subject Headings

  • Translational Research, Biomedical
  • Smoking Cessation
  • Pharmacology & Pharmacy
  • Pharmacogenetics
  • Neuroimaging
  • Humans
  • Drug Discovery
  • Biomarkers
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Bough, K. J., Lerman, C., Rose, J. E., McClernon, F. J., Kenny, P. J., Tyndale, R. F., … Amur, S. (2013). Biomarkers for smoking cessation. Clin Pharmacol Ther, 93(6), 526–538. https://doi.org/10.1038/clpt.2013.57
Bough, K. J., C. Lerman, J. E. Rose, F. J. McClernon, P. J. Kenny, R. F. Tyndale, S. P. David, et al. “Biomarkers for smoking cessation.Clin Pharmacol Ther 93, no. 6 (June 2013): 526–38. https://doi.org/10.1038/clpt.2013.57.
Bough KJ, Lerman C, Rose JE, McClernon FJ, Kenny PJ, Tyndale RF, et al. Biomarkers for smoking cessation. Clin Pharmacol Ther. 2013 Jun;93(6):526–38.
Bough, K. J., et al. “Biomarkers for smoking cessation.Clin Pharmacol Ther, vol. 93, no. 6, June 2013, pp. 526–38. Pubmed, doi:10.1038/clpt.2013.57.
Bough KJ, Lerman C, Rose JE, McClernon FJ, Kenny PJ, Tyndale RF, David SP, Stein EA, Uhl GR, Conti DV, Green C, Amur S. Biomarkers for smoking cessation. Clin Pharmacol Ther. 2013 Jun;93(6):526–538.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

June 2013

Volume

93

Issue

6

Start / End Page

526 / 538

Location

United States

Related Subject Headings

  • Translational Research, Biomedical
  • Smoking Cessation
  • Pharmacology & Pharmacy
  • Pharmacogenetics
  • Neuroimaging
  • Humans
  • Drug Discovery
  • Biomarkers
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences