Scholars@Duke

Synthesis of β2-AR agonist BI-167107

Publication ,  Journal Article
Wang, J; Seungkirl, A; Kahsai, AW; Liu, R; Ren, J; Hu, K; Sun, X; Chen, X
Published in: Chinese Journal of Organic Chemistry
March 1, 2013
Published version (DOI)

BI-167107 is a new long-acting β2-adrenergic receptor (β2-AR) agonist, and has important application in determining the critical structures of receptor/ligand proteins complex of G-protein-coupled receptor (GPCR). By employing 2-nitroresorcinol as starting material, a practical synthetic route for BI-167107 has been developed, involving 7-step reactions. The structure of the target molecule has been confirmed by 1H NMR, 13C NMR and MS techniques. The advantages of the synthetic route include avoiding use of toxic reagents and being suitable for scale up preparation of BI-167107 and other benzoxazine derivatives. © 2013 Chinese Chemical Society and SIOC, CAS.

Duke Scholars

Seungkirl Ahn
Author Seungkirl Ahn Medicine, Cardiology
Alem W Kahsai
Author Alem W Kahsai Medicine, Cardiology

Published In

Chinese Journal of Organic Chemistry

DOI

10.6023/cjoc201211015

ISSN

0253-2786

Publication Date

March 1, 2013

Volume

33

Issue

3

Start / End Page

634 / 639

Related Subject Headings

  • Organic Chemistry
  • 3405 Organic chemistry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, J., Seungkirl, A., Kahsai, A. W., Liu, R., Ren, J., Hu, K., … Chen, X. (2013). Synthesis of β2-AR agonist BI-167107. Chinese Journal of Organic Chemistry, 33(3), 634–639. https://doi.org/10.6023/cjoc201211015
Wang, J., A. Seungkirl, A. W. Kahsai, R. Liu, J. Ren, K. Hu, X. Sun, and X. Chen. “Synthesis of β2-AR agonist BI-167107.” Chinese Journal of Organic Chemistry 33, no. 3 (March 1, 2013): 634–39. https://doi.org/10.6023/cjoc201211015.
Wang J, Seungkirl A, Kahsai AW, Liu R, Ren J, Hu K, et al. Synthesis of β2-AR agonist BI-167107. Chinese Journal of Organic Chemistry. 2013 Mar 1;33(3):634–9.
Wang, J., et al. “Synthesis of β2-AR agonist BI-167107.” Chinese Journal of Organic Chemistry, vol. 33, no. 3, Mar. 2013, pp. 634–39. Scopus, doi:10.6023/cjoc201211015.
Wang J, Seungkirl A, Kahsai AW, Liu R, Ren J, Hu K, Sun X, Chen X. Synthesis of β2-AR agonist BI-167107. Chinese Journal of Organic Chemistry. 2013 Mar 1;33(3):634–639.

Published In

Chinese Journal of Organic Chemistry

DOI

10.6023/cjoc201211015

ISSN

0253-2786

Publication Date

March 1, 2013

Volume

33

Issue

3

Start / End Page

634 / 639

Related Subject Headings

  • Organic Chemistry
  • 3405 Organic chemistry