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Feasibility and preliminary efficacy data from a computerized cognitive intervention in children with chromosome 22q11.2 deletion syndrome.

Publication ,  Journal Article
Harrell, W; Eack, S; Hooper, SR; Keshavan, MS; Bonner, MS; Schoch, K; Shashi, V
Published in: Res Dev Disabil
September 2013

Children with chromosome 22q11.2 deletion syndrome (22q11DS) are significantly impaired in their academic performance and functionality due to cognitive deficits, especially in attention, memory, and other facets of executive function. Compounding these cognitive deficits is the remarkably high risk of major psychoses, occurring in 25% of adolescents and adults with the disorder. There are currently no evidence-based interventions designed to improve the cognitive deficits in these individuals. We implemented a neuroplasticity-based computerized cognitive remediation program for 12 weeks in 13 adolescents with 22q11DS, assessed feasibility, and measured changes in cognition before and after the intervention compared to a control group of 10 age- and gender-matched children with 22q11DS. Our results indicated that despite their cognitive impairments, this intervention is feasible in children with 22q11DS, with high rates of adherence and satisfaction. Our preliminary analyses indicate that gains in cognition occur with the intervention. Further study in a larger randomized controlled trial would enable assessment of efficacy of this novel intervention.

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Published In

Res Dev Disabil

DOI

EISSN

1873-3379

Publication Date

September 2013

Volume

34

Issue

9

Start / End Page

2606 / 2613

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Therapy, Computer-Assisted
  • Reproducibility of Results
  • Rehabilitation
  • Pilot Projects
  • Neuronal Plasticity
  • Memory
  • Male
  • Humans
  • Female
 

Citation

APA
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ICMJE
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Harrell, W., Eack, S., Hooper, S. R., Keshavan, M. S., Bonner, M. S., Schoch, K., & Shashi, V. (2013). Feasibility and preliminary efficacy data from a computerized cognitive intervention in children with chromosome 22q11.2 deletion syndrome. Res Dev Disabil, 34(9), 2606–2613. https://doi.org/10.1016/j.ridd.2013.05.009
Harrell, Waverly, Shaun Eack, Stephen R. Hooper, Matcheri S. Keshavan, Melanie S. Bonner, Kelly Schoch, and Vandana Shashi. “Feasibility and preliminary efficacy data from a computerized cognitive intervention in children with chromosome 22q11.2 deletion syndrome.Res Dev Disabil 34, no. 9 (September 2013): 2606–13. https://doi.org/10.1016/j.ridd.2013.05.009.
Harrell W, Eack S, Hooper SR, Keshavan MS, Bonner MS, Schoch K, et al. Feasibility and preliminary efficacy data from a computerized cognitive intervention in children with chromosome 22q11.2 deletion syndrome. Res Dev Disabil. 2013 Sep;34(9):2606–13.
Harrell, Waverly, et al. “Feasibility and preliminary efficacy data from a computerized cognitive intervention in children with chromosome 22q11.2 deletion syndrome.Res Dev Disabil, vol. 34, no. 9, Sept. 2013, pp. 2606–13. Pubmed, doi:10.1016/j.ridd.2013.05.009.
Harrell W, Eack S, Hooper SR, Keshavan MS, Bonner MS, Schoch K, Shashi V. Feasibility and preliminary efficacy data from a computerized cognitive intervention in children with chromosome 22q11.2 deletion syndrome. Res Dev Disabil. 2013 Sep;34(9):2606–2613.
Journal cover image

Published In

Res Dev Disabil

DOI

EISSN

1873-3379

Publication Date

September 2013

Volume

34

Issue

9

Start / End Page

2606 / 2613

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Therapy, Computer-Assisted
  • Reproducibility of Results
  • Rehabilitation
  • Pilot Projects
  • Neuronal Plasticity
  • Memory
  • Male
  • Humans
  • Female