Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Impact of offspring death on cognitive health in late life: the Cache County study.

Publication ,  Journal Article
Greene, D; Tschanz, JT; Smith, KR; Ostbye, T; Corcoran, C; Welsh-Bohmer, KA; Norton, MC; Cache County Investigators,
Published in: Am J Geriatr Psychiatry
November 2014

OBJECTIVE: Experiencing the death of a child is associated with negative short-term mental health consequences, but less is known about cognitive outcomes and whether such associations extend to late life. We tested the hypothesis that experiencing an offspring death (OD) is associated with an increased rate of cognitive decline in late life. METHODS: This population-based longitudinal study observed four cognitive statuses spaced 3-4 years apart, linked to an extensive database containing objective genealogic and vital statistics data. Home visits were conducted with 3,174 residents of a rural county in northern Utah, initially without dementia, aged 65-105. Cognitive status was measured with the Modified Mini-Mental State Exam at baseline and at 3-, 7-, and 10-year follow-ups. OD was obtained from the Utah Population Database, which contains statewide birth and death records. RESULTS: In linear mixed models, controlling for age, gender, education, and apolipoprotein E status, subjects who experienced OD while younger than age 31 years experienced a significantly faster rate of cognitive decline in late life, but only if they had an ε4 allele. Reclassifying all OD (regardless of age) according to subsequent birth of another child, OD was only related to faster cognitive decline when there were no subsequent births. CONCLUSION: Experiencing OD in early adulthood has a long-term association with cognitive functioning in late life, with a gene-environment interaction at the apolipoprotein E locus. Subsequent birth of another child attenuates this association.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Geriatr Psychiatry

DOI

EISSN

1545-7214

Publication Date

November 2014

Volume

22

Issue

11

Start / End Page

1307 / 1315

Location

England

Related Subject Headings

  • Young Adult
  • Utah
  • Sex Factors
  • Risk Factors
  • Parent-Child Relations
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Life Change Events
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Greene, D., Tschanz, J. T., Smith, K. R., Ostbye, T., Corcoran, C., Welsh-Bohmer, K. A., … Cache County Investigators, . (2014). Impact of offspring death on cognitive health in late life: the Cache County study. Am J Geriatr Psychiatry, 22(11), 1307–1315. https://doi.org/10.1016/j.jagp.2013.05.002
Greene, Daylee, JoAnn T. Tschanz, Ken R. Smith, Truls Ostbye, Chris Corcoran, Kathleen A. Welsh-Bohmer, Maria C. Norton, and Maria C. Cache County Investigators. “Impact of offspring death on cognitive health in late life: the Cache County study.Am J Geriatr Psychiatry 22, no. 11 (November 2014): 1307–15. https://doi.org/10.1016/j.jagp.2013.05.002.
Greene D, Tschanz JT, Smith KR, Ostbye T, Corcoran C, Welsh-Bohmer KA, et al. Impact of offspring death on cognitive health in late life: the Cache County study. Am J Geriatr Psychiatry. 2014 Nov;22(11):1307–15.
Greene, Daylee, et al. “Impact of offspring death on cognitive health in late life: the Cache County study.Am J Geriatr Psychiatry, vol. 22, no. 11, Nov. 2014, pp. 1307–15. Pubmed, doi:10.1016/j.jagp.2013.05.002.
Greene D, Tschanz JT, Smith KR, Ostbye T, Corcoran C, Welsh-Bohmer KA, Norton MC, Cache County Investigators. Impact of offspring death on cognitive health in late life: the Cache County study. Am J Geriatr Psychiatry. 2014 Nov;22(11):1307–1315.
Journal cover image

Published In

Am J Geriatr Psychiatry

DOI

EISSN

1545-7214

Publication Date

November 2014

Volume

22

Issue

11

Start / End Page

1307 / 1315

Location

England

Related Subject Headings

  • Young Adult
  • Utah
  • Sex Factors
  • Risk Factors
  • Parent-Child Relations
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Life Change Events
  • Humans