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Development and application of a suite of 4-D virtual breast phantoms for optimization and evaluation of breast imaging systems.

Publication ,  Journal Article
Kiarashi, N; Lo, JY; Lin, Y; Ikejimba, LC; Ghate, SV; Nolte, LW; Dobbins, JT; Segars, WP; Samei, E
Published in: IEEE Trans Med Imaging
July 2014

Mammography is currently the most widely utilized tool for detection and diagnosis of breast cancer. However, in women with dense breast tissue, tissue overlap may obscure lesions. Digital breast tomosynthesis can reduce tissue overlap. Furthermore, imaging with contrast enhancement can provide additional functional information about lesions, such as morphology and kinetics, which in turn may improve lesion identification and characterization. The performance of these imaging techniques is strongly dependent on the structural composition of the breast, which varies significantly among patients. Therefore, imaging system and imaging technique optimization should take patient variability into consideration. Furthermore, optimization of imaging techniques that employ contrast agents should include the temporally varying breast composition with respect to the contrast agent uptake kinetics. To these ends, we have developed a suite of 4-D virtual breast phantoms, which are incorporated with the kinetics of contrast agent propagation in different tissues and can realistically model normal breast parenchyma as well as benign and malignant lesions. This development presents a new approach in performing simulation studies using truly anthropomorphic models. To demonstrate the utility of the proposed 4-D phantoms, we present a simplified example study to compare the performance of 14 imaging paradigms qualitatively and quantitatively.

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Published In

IEEE Trans Med Imaging

DOI

EISSN

1558-254X

Publication Date

July 2014

Volume

33

Issue

7

Start / End Page

1401 / 1409

Location

United States

Related Subject Headings

  • Signal-To-Noise Ratio
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Mammography
  • Imaging, Three-Dimensional
  • Image Interpretation, Computer-Assisted
  • Humans
  • Female
  • Contrast Media
  • Breast Neoplasms
 

Citation

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Kiarashi, N., Lo, J. Y., Lin, Y., Ikejimba, L. C., Ghate, S. V., Nolte, L. W., … Samei, E. (2014). Development and application of a suite of 4-D virtual breast phantoms for optimization and evaluation of breast imaging systems. IEEE Trans Med Imaging, 33(7), 1401–1409. https://doi.org/10.1109/TMI.2014.2312733
Kiarashi, Nooshin, Joseph Y. Lo, Yuan Lin, Lynda C. Ikejimba, Sujata V. Ghate, Loren W. Nolte, James T. Dobbins, William P. Segars, and Ehsan Samei. “Development and application of a suite of 4-D virtual breast phantoms for optimization and evaluation of breast imaging systems.IEEE Trans Med Imaging 33, no. 7 (July 2014): 1401–9. https://doi.org/10.1109/TMI.2014.2312733.
Kiarashi N, Lo JY, Lin Y, Ikejimba LC, Ghate SV, Nolte LW, et al. Development and application of a suite of 4-D virtual breast phantoms for optimization and evaluation of breast imaging systems. IEEE Trans Med Imaging. 2014 Jul;33(7):1401–9.
Kiarashi, Nooshin, et al. “Development and application of a suite of 4-D virtual breast phantoms for optimization and evaluation of breast imaging systems.IEEE Trans Med Imaging, vol. 33, no. 7, July 2014, pp. 1401–09. Pubmed, doi:10.1109/TMI.2014.2312733.
Kiarashi N, Lo JY, Lin Y, Ikejimba LC, Ghate SV, Nolte LW, Dobbins JT, Segars WP, Samei E. Development and application of a suite of 4-D virtual breast phantoms for optimization and evaluation of breast imaging systems. IEEE Trans Med Imaging. 2014 Jul;33(7):1401–1409.

Published In

IEEE Trans Med Imaging

DOI

EISSN

1558-254X

Publication Date

July 2014

Volume

33

Issue

7

Start / End Page

1401 / 1409

Location

United States

Related Subject Headings

  • Signal-To-Noise Ratio
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Mammography
  • Imaging, Three-Dimensional
  • Image Interpretation, Computer-Assisted
  • Humans
  • Female
  • Contrast Media
  • Breast Neoplasms