Vancomycin cerebrospinal fluid pharmacokinetics in children with cerebral ventricular shunt infections.

Journal Article (Journal Article)

This study described the cerebrospinal fluid (CSF) exposure of vancomycin in 8 children prescribed intravenous vancomycin therapy for cerebral ventricular shunt infection. Vancomycin CSF concentrations ranged from 0.06 to 9.13 mg/L and the CSF: plasma ratio ranged from 0 to 0.66. Two of 3 children with a staphylococcal CSF infection had CSF concentrations greater than minimal inhibitory concentration at the end of the dosing interval.

Full Text

Duke Authors

Cited Authors

  • Autmizguine, J; Moran, C; Gonzalez, D; Capparelli, EV; Smith, PB; Grant, GA; Benjamin, DK; Cohen-Wolkowiez, M; Watt, KM

Published Date

  • October 2014

Published In

Volume / Issue

  • 33 / 10

Start / End Page

  • e270 - e272

PubMed ID

  • 24776517

Pubmed Central ID

  • PMC4209191

Electronic International Standard Serial Number (EISSN)

  • 1532-0987

Digital Object Identifier (DOI)

  • 10.1097/INF.0000000000000385


  • eng

Conference Location

  • United States