Vancomycin cerebrospinal fluid pharmacokinetics in children with cerebral ventricular shunt infections.
Journal Article (Journal Article)
This study described the cerebrospinal fluid (CSF) exposure of vancomycin in 8 children prescribed intravenous vancomycin therapy for cerebral ventricular shunt infection. Vancomycin CSF concentrations ranged from 0.06 to 9.13 mg/L and the CSF: plasma ratio ranged from 0 to 0.66. Two of 3 children with a staphylococcal CSF infection had CSF concentrations greater than minimal inhibitory concentration at the end of the dosing interval.
Full Text
Duke Authors
Cited Authors
- Autmizguine, J; Moran, C; Gonzalez, D; Capparelli, EV; Smith, PB; Grant, GA; Benjamin, DK; Cohen-Wolkowiez, M; Watt, KM
Published Date
- October 2014
Published In
Volume / Issue
- 33 / 10
Start / End Page
- e270 - e272
PubMed ID
- 24776517
Pubmed Central ID
- PMC4209191
Electronic International Standard Serial Number (EISSN)
- 1532-0987
Digital Object Identifier (DOI)
- 10.1097/INF.0000000000000385
Language
- eng
Conference Location
- United States