Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates.
To evaluate antibody specificities induced by simian immunodeficiency virus (SIV) versus human immunodeficiency virus type 1 (HIV-1) envelope antigens in nonhuman primate (NHP), we profiled binding antibody responses to linear epitopes in NHP studies with HIV-1 or SIV immunogens. We found that, overall, HIV-1 Env IgG responses were dominated by V3, with the notable exception of the responses to the vaccine strain A244 Env that were dominated by V2, whereas the anti-SIVmac239 Env responses were dominated by V2 regardless of the vaccine regimen.
Shen, X; Duffy, R; Howington, R; Cope, A; Sadagopal, S; Park, H; Pal, R; Kwa, S; Ding, S; Yang, OO; Fouda, GG; Le Grand, R; Bolton, D; Esteban, M; Phogat, S; Roederer, M; Amara, RR; Picker, LJ; Seder, RA; McElrath, MJ; Barnett, S; Permar, SR; Shattock, R; DeVico, AL; Felber, BK; Pavlakis, GN; Pantaleo, G; Korber, BT; Montefiori, DC; Tomaras, GD
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