Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates.
Publication
, Journal Article
Shen, X; Duffy, R; Howington, R; Cope, A; Sadagopal, S; Park, H; Pal, R; Kwa, S; Ding, S; Yang, OO; Fouda, GG; Le Grand, R; Bolton, D ...
Published in: J Virol
August 2015
To evaluate antibody specificities induced by simian immunodeficiency virus (SIV) versus human immunodeficiency virus type 1 (HIV-1) envelope antigens in nonhuman primate (NHP), we profiled binding antibody responses to linear epitopes in NHP studies with HIV-1 or SIV immunogens. We found that, overall, HIV-1 Env IgG responses were dominated by V3, with the notable exception of the responses to the vaccine strain A244 Env that were dominated by V2, whereas the anti-SIVmac239 Env responses were dominated by V2 regardless of the vaccine regimen.
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Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
August 2015
Volume
89
Issue
16
Start / End Page
8643 / 8650
Location
United States
Related Subject Headings
- Virology
- Viral Envelope Proteins
- Species Specificity
- Simian immunodeficiency virus
- Simian Immunodeficiency Virus
- Primates
- Microarray Analysis
- Immunoglobulin G
- HIV-1
- Epitopes
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Chicago
ICMJE
MLA
NLM
Shen, X., Duffy, R., Howington, R., Cope, A., Sadagopal, S., Park, H., … Tomaras, G. D. (2015). Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates. J Virol, 89(16), 8643–8650. https://doi.org/10.1128/JVI.03635-14
Shen, Xiaoying, Ryan Duffy, Robert Howington, Alethea Cope, Shanmugalakshmi Sadagopal, Haesun Park, Ranajit Pal, et al. “Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates.” J Virol 89, no. 16 (August 2015): 8643–50. https://doi.org/10.1128/JVI.03635-14.
Shen X, Duffy R, Howington R, Cope A, Sadagopal S, Park H, et al. Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates. J Virol. 2015 Aug;89(16):8643–50.
Shen, Xiaoying, et al. “Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates.” J Virol, vol. 89, no. 16, Aug. 2015, pp. 8643–50. Pubmed, doi:10.1128/JVI.03635-14.
Shen X, Duffy R, Howington R, Cope A, Sadagopal S, Park H, Pal R, Kwa S, Ding S, Yang OO, Fouda GG, Le Grand R, Bolton D, Esteban M, Phogat S, Roederer M, Amara RR, Picker LJ, Seder RA, McElrath MJ, Barnett S, Permar SR, Shattock R, DeVico AL, Felber BK, Pavlakis GN, Pantaleo G, Korber BT, Montefiori DC, Tomaras GD. Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates. J Virol. 2015 Aug;89(16):8643–8650.
Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
August 2015
Volume
89
Issue
16
Start / End Page
8643 / 8650
Location
United States
Related Subject Headings
- Virology
- Viral Envelope Proteins
- Species Specificity
- Simian immunodeficiency virus
- Simian Immunodeficiency Virus
- Primates
- Microarray Analysis
- Immunoglobulin G
- HIV-1
- Epitopes