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What was old is new again: using the host response to diagnose infectious disease.

Publication ,  Journal Article
Ko, ER; Yang, WE; McClain, MT; Woods, CW; Ginsburg, GS; Tsalik, EL
Published in: Expert Rev Mol Diagn
2015

A century of advances in infectious disease diagnosis and treatment changed the face of medicine. However, challenges continue to develop including multi-drug resistance, globalization that increases pandemic risks and high mortality from severe infections. These challenges can be mitigated through improved diagnostics, focusing on both pathogen discovery and the host response. Here, we review how 'omics' technologies improve sepsis diagnosis, early pathogen identification and personalize therapy. Such host response diagnostics are possible due to the confluence of advanced laboratory techniques (e.g., transcriptomics, metabolomics, proteomics) along with advanced mathematical modeling such as machine learning techniques. The road ahead is promising, but obstacles remain before the impact of such advanced diagnostic modalities is felt at the bedside.

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Published In

Expert Rev Mol Diagn

DOI

EISSN

1744-8352

Publication Date

2015

Volume

15

Issue

9

Start / End Page

1143 / 1158

Location

England

Related Subject Headings

  • Proteomics
  • Metabolomics
  • Humans
  • Host-Pathogen Interactions
  • Genomics
  • Early Diagnosis
  • Communicable Diseases
  • Biomarkers
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Chicago
ICMJE
MLA
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Ko, E. R., Yang, W. E., McClain, M. T., Woods, C. W., Ginsburg, G. S., & Tsalik, E. L. (2015). What was old is new again: using the host response to diagnose infectious disease. Expert Rev Mol Diagn, 15(9), 1143–1158. https://doi.org/10.1586/14737159.2015.1059278
Ko, Emily R., William E. Yang, Micah T. McClain, Christopher W. Woods, Geoffrey S. Ginsburg, and Ephraim L. Tsalik. “What was old is new again: using the host response to diagnose infectious disease.Expert Rev Mol Diagn 15, no. 9 (2015): 1143–58. https://doi.org/10.1586/14737159.2015.1059278.
Ko ER, Yang WE, McClain MT, Woods CW, Ginsburg GS, Tsalik EL. What was old is new again: using the host response to diagnose infectious disease. Expert Rev Mol Diagn. 2015;15(9):1143–58.
Ko, Emily R., et al. “What was old is new again: using the host response to diagnose infectious disease.Expert Rev Mol Diagn, vol. 15, no. 9, 2015, pp. 1143–58. Pubmed, doi:10.1586/14737159.2015.1059278.
Ko ER, Yang WE, McClain MT, Woods CW, Ginsburg GS, Tsalik EL. What was old is new again: using the host response to diagnose infectious disease. Expert Rev Mol Diagn. 2015;15(9):1143–1158.
Journal cover image

Published In

Expert Rev Mol Diagn

DOI

EISSN

1744-8352

Publication Date

2015

Volume

15

Issue

9

Start / End Page

1143 / 1158

Location

England

Related Subject Headings

  • Proteomics
  • Metabolomics
  • Humans
  • Host-Pathogen Interactions
  • Genomics
  • Early Diagnosis
  • Communicable Diseases
  • Biomarkers
  • 3202 Clinical sciences
  • 1103 Clinical Sciences