What was old is new again: using the host response to diagnose infectious disease.

Journal Article (Journal Article;Review)

A century of advances in infectious disease diagnosis and treatment changed the face of medicine. However, challenges continue to develop including multi-drug resistance, globalization that increases pandemic risks and high mortality from severe infections. These challenges can be mitigated through improved diagnostics, focusing on both pathogen discovery and the host response. Here, we review how 'omics' technologies improve sepsis diagnosis, early pathogen identification and personalize therapy. Such host response diagnostics are possible due to the confluence of advanced laboratory techniques (e.g., transcriptomics, metabolomics, proteomics) along with advanced mathematical modeling such as machine learning techniques. The road ahead is promising, but obstacles remain before the impact of such advanced diagnostic modalities is felt at the bedside.

Full Text

Duke Authors

Cited Authors

  • Ko, ER; Yang, WE; McClain, MT; Woods, CW; Ginsburg, GS; Tsalik, EL

Published Date

  • 2015

Published In

Volume / Issue

  • 15 / 9

Start / End Page

  • 1143 - 1158

PubMed ID

  • 26145249

Electronic International Standard Serial Number (EISSN)

  • 1744-8352

Digital Object Identifier (DOI)

  • 10.1586/14737159.2015.1059278


  • eng

Conference Location

  • England