Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation.

Published

Journal Article

Palmitic acid (PA) is associated with higher blood concentrations of medium-chain acylcarnitines (MCACs), and we hypothesized that PA may inhibit progression of FA β-oxidation. Using a cross-over design, 17 adults were fed high PA (HPA) and low PA/high oleic acid (HOA) diets, each for 3 weeks. The [1-(13)C]PA and [13-(13)C]PA tracers were administered with food in random order with each diet, and we assessed PA oxidation (PA OX) and serum AC concentration to determine whether a higher PA intake promoted incomplete PA OX. Dietary PA was completely oxidized during the HOA diet, but only about 40% was oxidized during the HPA diet. The [13-(13)C]PA/[1-(13)C]PA ratio of PA OX had an approximate value of 1.0 for either diet, but the ratio of the serum concentrations of MCACs to long-chain ACs (LCACs) was significantly higher during the HPA diet. Thus, direct measurement of PA OX did not confirm that the HPA diet caused incomplete PA OX, despite the modest, but statistically significant, increase in the ratio of MCACs to LCACs in blood.

Full Text

Duke Authors

Cited Authors

  • Kien, CL; Matthews, DE; Poynter, ME; Bunn, JY; Fukagawa, NK; Crain, KI; Ebenstein, DB; Tarleton, EK; Stevens, RD; Koves, TR; Muoio, DM

Published Date

  • September 2015

Published In

Volume / Issue

  • 56 / 9

Start / End Page

  • 1795 - 1807

PubMed ID

  • 26156077

Pubmed Central ID

  • 26156077

Electronic International Standard Serial Number (EISSN)

  • 1539-7262

International Standard Serial Number (ISSN)

  • 0022-2275

Digital Object Identifier (DOI)

  • 10.1194/jlr.M060137

Language

  • eng