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Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation.

Publication ,  Journal Article
Kien, CL; Matthews, DE; Poynter, ME; Bunn, JY; Fukagawa, NK; Crain, KI; Ebenstein, DB; Tarleton, EK; Stevens, RD; Koves, TR; Muoio, DM
Published in: J Lipid Res
September 2015

Palmitic acid (PA) is associated with higher blood concentrations of medium-chain acylcarnitines (MCACs), and we hypothesized that PA may inhibit progression of FA β-oxidation. Using a cross-over design, 17 adults were fed high PA (HPA) and low PA/high oleic acid (HOA) diets, each for 3 weeks. The [1-(13)C]PA and [13-(13)C]PA tracers were administered with food in random order with each diet, and we assessed PA oxidation (PA OX) and serum AC concentration to determine whether a higher PA intake promoted incomplete PA OX. Dietary PA was completely oxidized during the HOA diet, but only about 40% was oxidized during the HPA diet. The [13-(13)C]PA/[1-(13)C]PA ratio of PA OX had an approximate value of 1.0 for either diet, but the ratio of the serum concentrations of MCACs to long-chain ACs (LCACs) was significantly higher during the HPA diet. Thus, direct measurement of PA OX did not confirm that the HPA diet caused incomplete PA OX, despite the modest, but statistically significant, increase in the ratio of MCACs to LCACs in blood.

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Published In

J Lipid Res

DOI

EISSN

1539-7262

Publication Date

September 2015

Volume

56

Issue

9

Start / End Page

1795 / 1807

Location

United States

Related Subject Headings

  • Palmitates
  • Oleic Acid
  • Male
  • Lipid Peroxidation
  • Immunity, Innate
  • Humans
  • Female
  • Fatty Acids
  • Dietary Fats
  • Diet
 

Citation

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Kien, C. L., Matthews, D. E., Poynter, M. E., Bunn, J. Y., Fukagawa, N. K., Crain, K. I., … Muoio, D. M. (2015). Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation. J Lipid Res, 56(9), 1795–1807. https://doi.org/10.1194/jlr.M060137
Kien, C Lawrence, Dwight E. Matthews, Matthew E. Poynter, Janice Y. Bunn, Naomi K. Fukagawa, Karen I. Crain, David B. Ebenstein, et al. “Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation.J Lipid Res 56, no. 9 (September 2015): 1795–1807. https://doi.org/10.1194/jlr.M060137.
Kien CL, Matthews DE, Poynter ME, Bunn JY, Fukagawa NK, Crain KI, et al. Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation. J Lipid Res. 2015 Sep;56(9):1795–807.
Kien, C. Lawrence, et al. “Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation.J Lipid Res, vol. 56, no. 9, Sept. 2015, pp. 1795–807. Pubmed, doi:10.1194/jlr.M060137.
Kien CL, Matthews DE, Poynter ME, Bunn JY, Fukagawa NK, Crain KI, Ebenstein DB, Tarleton EK, Stevens RD, Koves TR, Muoio DM. Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation. J Lipid Res. 2015 Sep;56(9):1795–1807.

Published In

J Lipid Res

DOI

EISSN

1539-7262

Publication Date

September 2015

Volume

56

Issue

9

Start / End Page

1795 / 1807

Location

United States

Related Subject Headings

  • Palmitates
  • Oleic Acid
  • Male
  • Lipid Peroxidation
  • Immunity, Innate
  • Humans
  • Female
  • Fatty Acids
  • Dietary Fats
  • Diet