Incidence of Breakthrough Urinary Tract Infection in Hospitalized Infants Receiving Antibiotic Prophylaxis.

Journal Article (Journal Article)

Urinary tract infections (UTIs) are a source of substantial morbidity in children in the neonatal intensive care unit. The incidence of UTIs that occur in critically ill infants during a course of antibiotic prophylaxis (i.e., breakthrough urinary tract infections [BUTIs]) is not known. We investigated the incidence of BUTI in a cohort of infants hospitalized on prophylactic antibiotics in neonatal intensive care units. Predictors of BUTI were evaluated using multivariable Cox regression. Out of 716 787 infants, 631 (0.09%) were prescribed 821 courses of antibiotic prophylaxis. Among this cohort, 60 infants (9.5%) suffered a total of 65 BUTIs. Of all prophylactic antibiotic courses, 65/821 (7.9%) were complicated by BUTI. Klebsiella, Enterobacter, and Escherichia coli species were the most common causes of BUTI. There was no statistically significant difference ( P = .78) in BUTI incidence among the 4 antibiotics assessed (amoxicillin, cephalexin, nitrofurantoin, or trimethoprim-sulfamethoxazole).

Full Text

Duke Authors

Cited Authors

  • Lloyd, JC; Hornik, CP; Benjamin, DK; Clark, RH; Routh, JC; Smith, PB

Published Date

  • January 2017

Published In

Volume / Issue

  • 56 / 1

Start / End Page

  • 65 - 70

PubMed ID

  • 27006413

Pubmed Central ID

  • 27006413

Electronic International Standard Serial Number (EISSN)

  • 1938-2707

Digital Object Identifier (DOI)

  • 10.1177/0009922816638664


  • eng

Conference Location

  • United States