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Incidence of Breakthrough Urinary Tract Infection in Hospitalized Infants Receiving Antibiotic Prophylaxis.

Publication ,  Journal Article
Lloyd, JC; Hornik, CP; Benjamin, DK; Clark, RH; Routh, JC; Smith, PB
Published in: Clin Pediatr (Phila)
January 2017

Urinary tract infections (UTIs) are a source of substantial morbidity in children in the neonatal intensive care unit. The incidence of UTIs that occur in critically ill infants during a course of antibiotic prophylaxis (i.e., breakthrough urinary tract infections [BUTIs]) is not known. We investigated the incidence of BUTI in a cohort of infants hospitalized on prophylactic antibiotics in neonatal intensive care units. Predictors of BUTI were evaluated using multivariable Cox regression. Out of 716 787 infants, 631 (0.09%) were prescribed 821 courses of antibiotic prophylaxis. Among this cohort, 60 infants (9.5%) suffered a total of 65 BUTIs. Of all prophylactic antibiotic courses, 65/821 (7.9%) were complicated by BUTI. Klebsiella, Enterobacter, and Escherichia coli species were the most common causes of BUTI. There was no statistically significant difference ( P = .78) in BUTI incidence among the 4 antibiotics assessed (amoxicillin, cephalexin, nitrofurantoin, or trimethoprim-sulfamethoxazole).

Duke Scholars

Published In

Clin Pediatr (Phila)

DOI

EISSN

1938-2707

Publication Date

January 2017

Volume

56

Issue

1

Start / End Page

65 / 70

Location

United States

Related Subject Headings

  • Pediatrics
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

APA
Chicago
ICMJE
MLA
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Lloyd, J. C., Hornik, C. P., Benjamin, D. K., Clark, R. H., Routh, J. C., & Smith, P. B. (2017). Incidence of Breakthrough Urinary Tract Infection in Hospitalized Infants Receiving Antibiotic Prophylaxis. Clin Pediatr (Phila), 56(1), 65–70. https://doi.org/10.1177/0009922816638664
Lloyd, Jessica C., Christoph P. Hornik, Daniel K. Benjamin, Reese H. Clark, Jonathan C. Routh, and P Brian Smith. “Incidence of Breakthrough Urinary Tract Infection in Hospitalized Infants Receiving Antibiotic Prophylaxis.Clin Pediatr (Phila) 56, no. 1 (January 2017): 65–70. https://doi.org/10.1177/0009922816638664.
Lloyd JC, Hornik CP, Benjamin DK, Clark RH, Routh JC, Smith PB. Incidence of Breakthrough Urinary Tract Infection in Hospitalized Infants Receiving Antibiotic Prophylaxis. Clin Pediatr (Phila). 2017 Jan;56(1):65–70.
Lloyd, Jessica C., et al. “Incidence of Breakthrough Urinary Tract Infection in Hospitalized Infants Receiving Antibiotic Prophylaxis.Clin Pediatr (Phila), vol. 56, no. 1, Jan. 2017, pp. 65–70. Pubmed, doi:10.1177/0009922816638664.
Lloyd JC, Hornik CP, Benjamin DK, Clark RH, Routh JC, Smith PB. Incidence of Breakthrough Urinary Tract Infection in Hospitalized Infants Receiving Antibiotic Prophylaxis. Clin Pediatr (Phila). 2017 Jan;56(1):65–70.
Journal cover image

Published In

Clin Pediatr (Phila)

DOI

EISSN

1938-2707

Publication Date

January 2017

Volume

56

Issue

1

Start / End Page

65 / 70

Location

United States

Related Subject Headings

  • Pediatrics
  • 1114 Paediatrics and Reproductive Medicine