Host-Based Peripheral Blood Gene Expression Analysis for Diagnosis of Infectious Diseases.

Journal Article (Journal Article;Review)

Emerging pandemic infectious threats, inappropriate antibacterial use contributing to multidrug resistance, and increased morbidity and mortality from diagnostic delays all contribute to a need for improved diagnostics in the field of infectious diseases. Historically, diagnosis of infectious diseases has relied on pathogen detection; however, a novel concept to improve diagnostics in infectious diseases relies instead on the detection of changes in patterns of gene expression in circulating white blood cells in response to infection. Alterations in peripheral blood gene expression in the infected state are robust and reproducible, yielding diagnostic and prognostic information to help facilitate patient treatment decisions.

Full Text

Duke Authors

Cited Authors

  • Holcomb, ZE; Tsalik, EL; Woods, CW; McClain, MT

Published Date

  • February 2017

Published In

Volume / Issue

  • 55 / 2

Start / End Page

  • 360 - 368

PubMed ID

  • 27795332

Pubmed Central ID

  • PMC5277504

Electronic International Standard Serial Number (EISSN)

  • 1098-660X

Digital Object Identifier (DOI)

  • 10.1128/JCM.01057-16


  • eng

Conference Location

  • United States