Host-Based Peripheral Blood Gene Expression Analysis for Diagnosis of Infectious Diseases.
Publication
, Journal Article
Holcomb, ZE; Tsalik, EL; Woods, CW; McClain, MT
Published in: J Clin Microbiol
February 2017
Emerging pandemic infectious threats, inappropriate antibacterial use contributing to multidrug resistance, and increased morbidity and mortality from diagnostic delays all contribute to a need for improved diagnostics in the field of infectious diseases. Historically, diagnosis of infectious diseases has relied on pathogen detection; however, a novel concept to improve diagnostics in infectious diseases relies instead on the detection of changes in patterns of gene expression in circulating white blood cells in response to infection. Alterations in peripheral blood gene expression in the infected state are robust and reproducible, yielding diagnostic and prognostic information to help facilitate patient treatment decisions.
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Published In
J Clin Microbiol
DOI
EISSN
1098-660X
Publication Date
February 2017
Volume
55
Issue
2
Start / End Page
360 / 368
Location
United States
Related Subject Headings
- Molecular Diagnostic Techniques
- Microbiology
- Leukocytes
- Humans
- Gene Expression Profiling
- Communicable Diseases
- 3207 Medical microbiology
- 3202 Clinical sciences
- 11 Medical and Health Sciences
- 07 Agricultural and Veterinary Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Holcomb, Z. E., Tsalik, E. L., Woods, C. W., & McClain, M. T. (2017). Host-Based Peripheral Blood Gene Expression Analysis for Diagnosis of Infectious Diseases. J Clin Microbiol, 55(2), 360–368. https://doi.org/10.1128/JCM.01057-16
Holcomb, Zachary E., Ephraim L. Tsalik, Christopher W. Woods, and Micah T. McClain. “Host-Based Peripheral Blood Gene Expression Analysis for Diagnosis of Infectious Diseases.” J Clin Microbiol 55, no. 2 (February 2017): 360–68. https://doi.org/10.1128/JCM.01057-16.
Holcomb ZE, Tsalik EL, Woods CW, McClain MT. Host-Based Peripheral Blood Gene Expression Analysis for Diagnosis of Infectious Diseases. J Clin Microbiol. 2017 Feb;55(2):360–8.
Holcomb, Zachary E., et al. “Host-Based Peripheral Blood Gene Expression Analysis for Diagnosis of Infectious Diseases.” J Clin Microbiol, vol. 55, no. 2, Feb. 2017, pp. 360–68. Pubmed, doi:10.1128/JCM.01057-16.
Holcomb ZE, Tsalik EL, Woods CW, McClain MT. Host-Based Peripheral Blood Gene Expression Analysis for Diagnosis of Infectious Diseases. J Clin Microbiol. 2017 Feb;55(2):360–368.
Published In
J Clin Microbiol
DOI
EISSN
1098-660X
Publication Date
February 2017
Volume
55
Issue
2
Start / End Page
360 / 368
Location
United States
Related Subject Headings
- Molecular Diagnostic Techniques
- Microbiology
- Leukocytes
- Humans
- Gene Expression Profiling
- Communicable Diseases
- 3207 Medical microbiology
- 3202 Clinical sciences
- 11 Medical and Health Sciences
- 07 Agricultural and Veterinary Sciences