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Timing of Multiorgan Dysfunction among Hospitalized Infants with Fatal Fulminant Sepsis.

Publication ,  Journal Article
Wynn, JL; Kelly, MS; Benjamin, DK; Clark, RH; Greenberg, R; Smith, PB
Published in: Am J Perinatol
June 2017

Objective Identify the progression of specific signs of multiorgan dysfunction among infants with fatal sepsis. Study Design Cohort study of 679 infants who died within 3 days of the start of a late-onset sepsis (LOS) episode in neonatal intensive care units from 1997 to 2012. We extracted clinical and laboratory data on the day of death (day 0) and the preceding 5 days (days -5 to -1). Results Median (25th percentile-75th percentile) gestational age was 25 (24-28) weeks. Compared with day -1, day 0 was characterized by an increased requirement for mechanical ventilation and higher mean fraction of inspired oxygen. Measures of cardiorespiratory support and the proportion of infants with neutropenia began to rise on day -2. Conclusion Hospitalized infants with fatal LOS manifest respiratory, cardiovascular, renal, immune, and hematologic dysfunction. Knowledge of these factors and their timing may be important for the development and testing of novel therapeutics to reduce sepsis mortality.

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Published In

Am J Perinatol

DOI

EISSN

1098-8785

Publication Date

June 2017

Volume

34

Issue

7

Start / End Page

633 / 639

Location

United States

Related Subject Headings

  • United States
  • Time Factors
  • Sepsis
  • Risk Factors
  • Respiration, Artificial
  • Prospective Studies
  • Oxygen Inhalation Therapy
  • Obstetrics & Reproductive Medicine
  • Multiple Organ Failure
  • Male
 

Citation

APA
Chicago
ICMJE
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Wynn, J. L., Kelly, M. S., Benjamin, D. K., Clark, R. H., Greenberg, R., & Smith, P. B. (2017). Timing of Multiorgan Dysfunction among Hospitalized Infants with Fatal Fulminant Sepsis. Am J Perinatol, 34(7), 633–639. https://doi.org/10.1055/s-0036-1597130
Wynn, James L., Matthew S. Kelly, Daniel K. Benjamin, Reese H. Clark, Rachel Greenberg, and P Brian Smith. “Timing of Multiorgan Dysfunction among Hospitalized Infants with Fatal Fulminant Sepsis.Am J Perinatol 34, no. 7 (June 2017): 633–39. https://doi.org/10.1055/s-0036-1597130.
Wynn JL, Kelly MS, Benjamin DK, Clark RH, Greenberg R, Smith PB. Timing of Multiorgan Dysfunction among Hospitalized Infants with Fatal Fulminant Sepsis. Am J Perinatol. 2017 Jun;34(7):633–9.
Wynn, James L., et al. “Timing of Multiorgan Dysfunction among Hospitalized Infants with Fatal Fulminant Sepsis.Am J Perinatol, vol. 34, no. 7, June 2017, pp. 633–39. Pubmed, doi:10.1055/s-0036-1597130.
Wynn JL, Kelly MS, Benjamin DK, Clark RH, Greenberg R, Smith PB. Timing of Multiorgan Dysfunction among Hospitalized Infants with Fatal Fulminant Sepsis. Am J Perinatol. 2017 Jun;34(7):633–639.
Journal cover image

Published In

Am J Perinatol

DOI

EISSN

1098-8785

Publication Date

June 2017

Volume

34

Issue

7

Start / End Page

633 / 639

Location

United States

Related Subject Headings

  • United States
  • Time Factors
  • Sepsis
  • Risk Factors
  • Respiration, Artificial
  • Prospective Studies
  • Oxygen Inhalation Therapy
  • Obstetrics & Reproductive Medicine
  • Multiple Organ Failure
  • Male