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Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery.

Publication ,  Journal Article
McDonnell, DP; Norris, JD; Chang, C-Y
Published in: Cancer Cell
February 12, 2018

In this issue of Cancer Cell, Jeselsohn et al. dissect the function of several of the most clinically important estrogen receptor alpha mutants associated with endocrine therapy resistance in breast cancer and demonstrate that they manifest disease-relevant neomorphic activities that likely contribute to tumor pathogenesis.

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Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

February 12, 2018

Volume

33

Issue

2

Start / End Page

153 / 155

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Mutation
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Estrogen Receptor alpha
  • Drug Resistance, Neoplasm
  • Drug Discovery
  • Cell Line, Tumor
  • Breast Neoplasms
  • 3211 Oncology and carcinogenesis
 

Citation

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McDonnell, D. P., Norris, J. D., & Chang, C.-Y. (2018). Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery. Cancer Cell, 33(2), 153–155. https://doi.org/10.1016/j.ccell.2018.01.014
McDonnell, Donald P., John D. Norris, and Ching-Yi Chang. “Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery.Cancer Cell 33, no. 2 (February 12, 2018): 153–55. https://doi.org/10.1016/j.ccell.2018.01.014.
McDonnell DP, Norris JD, Chang C-Y. Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery. Cancer Cell. 2018 Feb 12;33(2):153–5.
McDonnell, Donald P., et al. “Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery.Cancer Cell, vol. 33, no. 2, Feb. 2018, pp. 153–55. Pubmed, doi:10.1016/j.ccell.2018.01.014.
McDonnell DP, Norris JD, Chang C-Y. Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery. Cancer Cell. 2018 Feb 12;33(2):153–155.
Journal cover image

Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

February 12, 2018

Volume

33

Issue

2

Start / End Page

153 / 155

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Mutation
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Estrogen Receptor alpha
  • Drug Resistance, Neoplasm
  • Drug Discovery
  • Cell Line, Tumor
  • Breast Neoplasms
  • 3211 Oncology and carcinogenesis