Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery.

Journal Article (Journal Article)

In this issue of Cancer Cell, Jeselsohn et al. dissect the function of several of the most clinically important estrogen receptor alpha mutants associated with endocrine therapy resistance in breast cancer and demonstrate that they manifest disease-relevant neomorphic activities that likely contribute to tumor pathogenesis.

Full Text

Duke Authors

Cited Authors

  • McDonnell, DP; Norris, JD; Chang, C-Y

Published Date

  • February 12, 2018

Published In

Volume / Issue

  • 33 / 2

Start / End Page

  • 153 - 155

PubMed ID

  • 29438688

Electronic International Standard Serial Number (EISSN)

  • 1878-3686

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2018.01.014


  • eng

Conference Location

  • United States