Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery.
Published
Journal Article
In this issue of Cancer Cell, Jeselsohn et al. dissect the function of several of the most clinically important estrogen receptor alpha mutants associated with endocrine therapy resistance in breast cancer and demonstrate that they manifest disease-relevant neomorphic activities that likely contribute to tumor pathogenesis.
Full Text
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Duke Authors
Cited Authors
- McDonnell, DP; Norris, JD; Chang, C-Y
Published Date
- February 12, 2018
Published In
Volume / Issue
- 33 / 2
Start / End Page
- 153 - 155
PubMed ID
- 29438688
Pubmed Central ID
- 29438688
Electronic International Standard Serial Number (EISSN)
- 1878-3686
Digital Object Identifier (DOI)
- 10.1016/j.ccell.2018.01.014
Language
- eng
Conference Location
- United States