Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery.
Publication
, Journal Article
McDonnell, DP; Norris, JD; Chang, C-Y
Published in: Cancer Cell
February 12, 2018
In this issue of Cancer Cell, Jeselsohn et al. dissect the function of several of the most clinically important estrogen receptor alpha mutants associated with endocrine therapy resistance in breast cancer and demonstrate that they manifest disease-relevant neomorphic activities that likely contribute to tumor pathogenesis.
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Published In
Cancer Cell
DOI
EISSN
1878-3686
Publication Date
February 12, 2018
Volume
33
Issue
2
Start / End Page
153 / 155
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Mutation
- Humans
- Gene Expression Regulation, Neoplastic
- Estrogen Receptor alpha
- Drug Resistance, Neoplasm
- Drug Discovery
- Cell Line, Tumor
- Breast Neoplasms
- 3211 Oncology and carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
McDonnell, D. P., Norris, J. D., & Chang, C.-Y. (2018). Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery. Cancer Cell, 33(2), 153–155. https://doi.org/10.1016/j.ccell.2018.01.014
McDonnell, Donald P., John D. Norris, and Ching-Yi Chang. “Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery.” Cancer Cell 33, no. 2 (February 12, 2018): 153–55. https://doi.org/10.1016/j.ccell.2018.01.014.
McDonnell DP, Norris JD, Chang C-Y. Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery. Cancer Cell. 2018 Feb 12;33(2):153–5.
McDonnell, Donald P., et al. “Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery.” Cancer Cell, vol. 33, no. 2, Feb. 2018, pp. 153–55. Pubmed, doi:10.1016/j.ccell.2018.01.014.
McDonnell DP, Norris JD, Chang C-Y. Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery. Cancer Cell. 2018 Feb 12;33(2):153–155.
Published In
Cancer Cell
DOI
EISSN
1878-3686
Publication Date
February 12, 2018
Volume
33
Issue
2
Start / End Page
153 / 155
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Mutation
- Humans
- Gene Expression Regulation, Neoplastic
- Estrogen Receptor alpha
- Drug Resistance, Neoplasm
- Drug Discovery
- Cell Line, Tumor
- Breast Neoplasms
- 3211 Oncology and carcinogenesis