Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers.

Published

Journal Article

Metabolic reprogramming provides critical information for clinical oncology. Using molecular data of 9,125 patient samples from The Cancer Genome Atlas, we identified tumor subtypes in 33 cancer types based on mRNA expression patterns of seven major metabolic processes and assessed their clinical relevance. Our metabolic expression subtypes correlated extensively with clinical outcome: subtypes with upregulated carbohydrate, nucleotide, and vitamin/cofactor metabolism most consistently correlated with worse prognosis, whereas subtypes with upregulated lipid metabolism showed the opposite. Metabolic subtypes correlated with diverse somatic drivers but exhibited effects convergent on cancer hallmark pathways and were modulated by highly recurrent master regulators across cancer types. As a proof-of-concept example, we demonstrated that knockdown of SNAI1 or RUNX1-master regulators of carbohydrate metabolic subtypes-modulates metabolic activity and drug sensitivity. Our study provides a system-level view of metabolic heterogeneity within and across cancer types and identifies pathway cross-talk, suggesting related prognostic, therapeutic, and predictive utility.

Full Text

Duke Authors

Cited Authors

  • Peng, X; Chen, Z; Farshidfar, F; Xu, X; Lorenzi, PL; Wang, Y; Cheng, F; Tan, L; Mojumdar, K; Du, D; Ge, Z; Li, J; Thomas, GV; Birsoy, K; Liu, L; Zhang, H; Zhao, Z; Marchand, C; Weinstein, JN; Cancer Genome Atlas Research Network, ; Bathe, OF; Liang, H

Published Date

  • April 3, 2018

Published In

Volume / Issue

  • 23 / 1

Start / End Page

  • 255 - 269.e4

PubMed ID

  • 29617665

Pubmed Central ID

  • 29617665

Electronic International Standard Serial Number (EISSN)

  • 2211-1247

Digital Object Identifier (DOI)

  • 10.1016/j.celrep.2018.03.077

Language

  • eng

Conference Location

  • United States