Heart Failure With Preserved Ejection Fraction Expert Panel Report: Current Controversies and Implications for Clinical Trials.


Journal Article (Review)

The number of persons with heart failure has continued to rise over the last several years. Approximately one-half of those living with heart failure have heart failure with preserved ejection fraction, but critical unsolved questions remain across the spectrum of basic, translational, clinical, and population research in heart failure with preserved ejection fraction. In this study, the authors summarize existing knowledge, persistent controversies, and gaps in evidence with regard to the understanding of heart failure with preserved ejection fraction. Our analysis is based on an expert panel discussion "Think Tank" meeting that included representatives from academia, the National Institutes of Health, the U.S. Food and Drug Administration, the Centers for Medicare & Medicaid Services, and industry.

Full Text

Duke Authors

Cited Authors

  • Parikh, KS; Sharma, K; Fiuzat, M; Surks, HK; George, JT; Honarpour, N; Depre, C; Desvigne-Nickens, P; Nkulikiyinka, R; Lewis, GD; Gomberg-Maitland, M; O'Connor, CM; Stockbridge, N; Califf, RM; Konstam, MA; Januzzi, JL; Solomon, SD; Borlaug, BA; Shah, SJ; Redfield, MM; Felker, GM

Published Date

  • August 2018

Published In

Volume / Issue

  • 6 / 8

Start / End Page

  • 619 - 632

PubMed ID

  • 30071950

Pubmed Central ID

  • 30071950

Electronic International Standard Serial Number (EISSN)

  • 2213-1787

Digital Object Identifier (DOI)

  • 10.1016/j.jchf.2018.06.008


  • eng

Conference Location

  • United States