Circulating microRNA plasma profile in MuSK+ myasthenia gravis.

Journal Article (Journal Article)

Muscle-specific tyrosine kinase antibody positive myasthenia gravis (MuSK+ MG) is an immunological subtype with distinctive pathogenic mechanisms and clinical features. The aim of this study was to analyze the circulating plasma microRNA profile of patients with MuSK+ MG. From the discovery cohort miR-210-3p, miR-324-3p and miR-328-3p were further analyzed in the validation cohort. We found a distinct plasma profile of miR-210-3p and miR-324-3p that were significantly decreased in MuSK+ MG patients compared to healthy controls (4.1 ± 1.4 vs 5.1 ± 1.4, p = .006 and 4.7 ± 1.0 vs 5.4 ± 1.3, p = .02). These findings reveal a distinct plasma miRNA profile in MuSK+ MG.

Full Text

Duke Authors

Cited Authors

  • Sabre, L; Guptill, JT; Russo, M; Juel, VC; Massey, JM; Howard, JF; Hobson-Webb, LD; Punga, AR

Published Date

  • December 15, 2018

Published In

Volume / Issue

  • 325 /

Start / End Page

  • 87 - 91

PubMed ID

  • 30316681

Pubmed Central ID

  • PMC6240475

Electronic International Standard Serial Number (EISSN)

  • 1872-8421

Digital Object Identifier (DOI)

  • 10.1016/j.jneuroim.2018.10.003


  • eng

Conference Location

  • Netherlands