Circulating microRNA plasma profile in MuSK+ myasthenia gravis.
Journal Article (Journal Article)
Muscle-specific tyrosine kinase antibody positive myasthenia gravis (MuSK+ MG) is an immunological subtype with distinctive pathogenic mechanisms and clinical features. The aim of this study was to analyze the circulating plasma microRNA profile of patients with MuSK+ MG. From the discovery cohort miR-210-3p, miR-324-3p and miR-328-3p were further analyzed in the validation cohort. We found a distinct plasma profile of miR-210-3p and miR-324-3p that were significantly decreased in MuSK+ MG patients compared to healthy controls (4.1 ± 1.4 vs 5.1 ± 1.4, p = .006 and 4.7 ± 1.0 vs 5.4 ± 1.3, p = .02). These findings reveal a distinct plasma miRNA profile in MuSK+ MG.
Full Text
Duke Authors
Cited Authors
- Sabre, L; Guptill, JT; Russo, M; Juel, VC; Massey, JM; Howard, JF; Hobson-Webb, LD; Punga, AR
Published Date
- December 15, 2018
Published In
Volume / Issue
- 325 /
Start / End Page
- 87 - 91
PubMed ID
- 30316681
Pubmed Central ID
- PMC6240475
Electronic International Standard Serial Number (EISSN)
- 1872-8421
Digital Object Identifier (DOI)
- 10.1016/j.jneuroim.2018.10.003
Language
- eng
Conference Location
- Netherlands