Circulating microRNA plasma profile in MuSK+ myasthenia gravis.
Publication
, Journal Article
Sabre, L; Guptill, JT; Russo, M; Juel, VC; Massey, JM; Howard, JF; Hobson-Webb, LD; Punga, AR
Published in: J Neuroimmunol
December 15, 2018
Muscle-specific tyrosine kinase antibody positive myasthenia gravis (MuSK+ MG) is an immunological subtype with distinctive pathogenic mechanisms and clinical features. The aim of this study was to analyze the circulating plasma microRNA profile of patients with MuSK+ MG. From the discovery cohort miR-210-3p, miR-324-3p and miR-328-3p were further analyzed in the validation cohort. We found a distinct plasma profile of miR-210-3p and miR-324-3p that were significantly decreased in MuSK+ MG patients compared to healthy controls (4.1 ± 1.4 vs 5.1 ± 1.4, p = .006 and 4.7 ± 1.0 vs 5.4 ± 1.3, p = .02). These findings reveal a distinct plasma miRNA profile in MuSK+ MG.
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Published In
J Neuroimmunol
DOI
EISSN
1872-8421
Publication Date
December 15, 2018
Volume
325
Start / End Page
87 / 91
Location
Netherlands
Related Subject Headings
- Receptors, Cholinergic
- Receptor Protein-Tyrosine Kinases
- Neurology & Neurosurgery
- Myasthenia Gravis
- Middle Aged
- Male
- Humans
- Female
- Cohort Studies
- Circulating MicroRNA
Citation
APA
Chicago
ICMJE
MLA
NLM
Sabre, L., Guptill, J. T., Russo, M., Juel, V. C., Massey, J. M., Howard, J. F., … Punga, A. R. (2018). Circulating microRNA plasma profile in MuSK+ myasthenia gravis. J Neuroimmunol, 325, 87–91. https://doi.org/10.1016/j.jneuroim.2018.10.003
Sabre, Liis, Jeffrey T. Guptill, Melissa Russo, Vern C. Juel, Janice M. Massey, James F. Howard, Lisa D. Hobson-Webb, and Anna Rostedt Punga. “Circulating microRNA plasma profile in MuSK+ myasthenia gravis.” J Neuroimmunol 325 (December 15, 2018): 87–91. https://doi.org/10.1016/j.jneuroim.2018.10.003.
Sabre L, Guptill JT, Russo M, Juel VC, Massey JM, Howard JF, et al. Circulating microRNA plasma profile in MuSK+ myasthenia gravis. J Neuroimmunol. 2018 Dec 15;325:87–91.
Sabre, Liis, et al. “Circulating microRNA plasma profile in MuSK+ myasthenia gravis.” J Neuroimmunol, vol. 325, Dec. 2018, pp. 87–91. Pubmed, doi:10.1016/j.jneuroim.2018.10.003.
Sabre L, Guptill JT, Russo M, Juel VC, Massey JM, Howard JF, Hobson-Webb LD, Punga AR. Circulating microRNA plasma profile in MuSK+ myasthenia gravis. J Neuroimmunol. 2018 Dec 15;325:87–91.
Published In
J Neuroimmunol
DOI
EISSN
1872-8421
Publication Date
December 15, 2018
Volume
325
Start / End Page
87 / 91
Location
Netherlands
Related Subject Headings
- Receptors, Cholinergic
- Receptor Protein-Tyrosine Kinases
- Neurology & Neurosurgery
- Myasthenia Gravis
- Middle Aged
- Male
- Humans
- Female
- Cohort Studies
- Circulating MicroRNA