Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries.

Journal Article (Journal Article)

AIMS/HYPOTHESIS: We aimed to determine the association of maternal metabolites with newborn adiposity and hyperinsulinaemia in a multi-ethnic cohort of mother-newborn dyads. METHODS: Targeted and non-targeted metabolomics assays were performed on fasting and 1 h serum samples from a total of 1600 mothers in four ancestry groups (Northern European, Afro-Caribbean, Mexican American and Thai) who participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study, underwent an OGTT at ~28 weeks gestation and whose newborns had anthropometric measurements at birth. RESULTS: In this observational study, meta-analyses demonstrated significant associations of maternal fasting and 1 h metabolites with birthweight, cord C-peptide and/or sum of skinfolds across ancestry groups. In particular, maternal fasting triacylglycerols were associated with newborn sum of skinfolds. At 1 h, several amino acids, fatty acids and lipid metabolites were associated with one or more newborn outcomes. Network analyses revealed clusters of fasting acylcarnitines, amino acids, lipids and fatty acid metabolites associated with cord C-peptide and sum of skinfolds, with the addition of branched-chain and aromatic amino acids at 1 h. CONCLUSIONS/INTERPRETATION: The maternal metabolome during pregnancy is associated with newborn outcomes. Maternal levels of amino acids, acylcarnitines, lipids and fatty acids and their metabolites during pregnancy relate to fetal growth, adiposity and cord C-peptide, independent of maternal BMI and blood glucose levels.

Full Text

Duke Authors

Cited Authors

  • Kadakia, R; Nodzenski, M; Talbot, O; Kuang, A; Bain, JR; Muehlbauer, MJ; Stevens, RD; Ilkayeva, OR; O'Neal, SK; Lowe, LP; Metzger, BE; Newgard, CB; Scholtens, DM; Lowe, WL; HAPO Study Cooperative Research Group,

Published Date

  • March 2019

Published In

Volume / Issue

  • 62 / 3

Start / End Page

  • 473 - 484

PubMed ID

  • 30483859

Pubmed Central ID

  • PMC6374187

Electronic International Standard Serial Number (EISSN)

  • 1432-0428

Digital Object Identifier (DOI)

  • 10.1007/s00125-018-4781-1


  • eng

Conference Location

  • Germany