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Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19.

Publication ,  Journal Article
Fudim, M; Qadri, YJ; Ghadimi, K; MacLeod, DB; Molinger, J; Piccini, JP; Whittle, J; Wischmeyer, PE; Patel, MR; Ulloa, L
Published in: J Cardiovasc Transl Res
December 2020

COVID-19 is a syndrome that includes more than just isolated respiratory disease, as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) also interacts with the cardiovascular, nervous, renal, and immune system at multiple levels, increasing morbidity in patients with underlying cardiometabolic conditions and inducing myocardial injury or dysfunction. Emerging evidence suggests that patients with the highest rate of morbidity and mortality following SARS-CoV2 infection have also developed a hyperinflammatory syndrome (also termed cytokine release syndrome). We lay out the potential contribution of a dysfunction in autonomic tone to the cytokine release syndrome and related multiorgan damage in COVID-19. We hypothesize that a cholinergic anti-inflammatory pathway could be targeted as a therapeutic avenue. Graphical Abstract .

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Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

December 2020

Volume

13

Issue

6

Start / End Page

894 / 899

Location

United States

Related Subject Headings

  • Vagus Nerve Stimulation
  • Treatment Outcome
  • SARS-CoV-2
  • Inflammation
  • Humans
  • Host-Pathogen Interactions
  • Cytokine Release Syndrome
  • Cholinergic Fibers
  • COVID-19 Drug Treatment
  • COVID-19
 

Citation

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Fudim, M., Qadri, Y. J., Ghadimi, K., MacLeod, D. B., Molinger, J., Piccini, J. P., … Ulloa, L. (2020). Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19. J Cardiovasc Transl Res, 13(6), 894–899. https://doi.org/10.1007/s12265-020-10031-6
Fudim, Marat, Yawar J. Qadri, Kamrouz Ghadimi, David B. MacLeod, Jeroen Molinger, Jonathan P. Piccini, John Whittle, Paul E. Wischmeyer, Manesh R. Patel, and Luis Ulloa. “Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19.J Cardiovasc Transl Res 13, no. 6 (December 2020): 894–99. https://doi.org/10.1007/s12265-020-10031-6.
Fudim M, Qadri YJ, Ghadimi K, MacLeod DB, Molinger J, Piccini JP, et al. Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19. J Cardiovasc Transl Res. 2020 Dec;13(6):894–9.
Fudim, Marat, et al. “Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19.J Cardiovasc Transl Res, vol. 13, no. 6, Dec. 2020, pp. 894–99. Pubmed, doi:10.1007/s12265-020-10031-6.
Fudim M, Qadri YJ, Ghadimi K, MacLeod DB, Molinger J, Piccini JP, Whittle J, Wischmeyer PE, Patel MR, Ulloa L. Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19. J Cardiovasc Transl Res. 2020 Dec;13(6):894–899.
Journal cover image

Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

December 2020

Volume

13

Issue

6

Start / End Page

894 / 899

Location

United States

Related Subject Headings

  • Vagus Nerve Stimulation
  • Treatment Outcome
  • SARS-CoV-2
  • Inflammation
  • Humans
  • Host-Pathogen Interactions
  • Cytokine Release Syndrome
  • Cholinergic Fibers
  • COVID-19 Drug Treatment
  • COVID-19