Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19.

Journal Article (Journal Article;Review)

COVID-19 is a syndrome that includes more than just isolated respiratory disease, as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) also interacts with the cardiovascular, nervous, renal, and immune system at multiple levels, increasing morbidity in patients with underlying cardiometabolic conditions and inducing myocardial injury or dysfunction. Emerging evidence suggests that patients with the highest rate of morbidity and mortality following SARS-CoV2 infection have also developed a hyperinflammatory syndrome (also termed cytokine release syndrome). We lay out the potential contribution of a dysfunction in autonomic tone to the cytokine release syndrome and related multiorgan damage in COVID-19. We hypothesize that a cholinergic anti-inflammatory pathway could be targeted as a therapeutic avenue. Graphical Abstract .

Full Text

Duke Authors

Cited Authors

  • Fudim, M; Qadri, YJ; Ghadimi, K; MacLeod, DB; Molinger, J; Piccini, JP; Whittle, J; Wischmeyer, PE; Patel, MR; Ulloa, L

Published Date

  • December 2020

Published In

Volume / Issue

  • 13 / 6

Start / End Page

  • 894 - 899

PubMed ID

  • 32458400

Pubmed Central ID

  • PMC7250255

Electronic International Standard Serial Number (EISSN)

  • 1937-5395

Digital Object Identifier (DOI)

  • 10.1007/s12265-020-10031-6


  • eng

Conference Location

  • United States