Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis.
Journal Article (Journal Article)
A detailed understanding of the role of Tfh cells in MuSK-antibody positive myasthenia gravis (MuSK-MG) is lacking. We characterized phenotype and function of Tfh cells in MuSK-MG patients and controls. We found similar overall Tfh and follicular regulatory (Tfr) T cell frequencies in MuSK-MG and healthy controls, but MuSK-MG patients exhibited higher frequencies of Tfh17 cells and a higher ratio of Tfh:Tfr cells. These results suggest imbalanced Tfh cell regulation, further supported by increased frequencies of CD4 T cells co-producing IL-21/IL-17 and IL-17/IFN-γ, and increased Tfh-supported IgG production. These results support a role for Tfh cell dysregulation in MuSK-MG immunopathology.
Full Text
Duke Authors
- Guptill, Jeffrey
- Hobson-Webb, Lisa Deneen
- Juel, Vern Charles
- Massey, Janice Munn
- Raja, Shruti Mukund
- Yi, John S
Cited Authors
- Li, Y; Guptill, JT; Russo, MA; Howard, JF; Massey, JM; Juel, VC; Hobson-Webb, LD; Emmett, D; Chopra, M; Raja, S; Liu, W; Yi, JS
Published Date
- August 15, 2020
Published In
Volume / Issue
- 345 /
Start / End Page
- 577279 -
PubMed ID
- 32497931
Pubmed Central ID
- PMC7397478
Electronic International Standard Serial Number (EISSN)
- 1872-8421
Digital Object Identifier (DOI)
- 10.1016/j.jneuroim.2020.577279
Language
- eng
Conference Location
- Netherlands