SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines.

Journal Article (Journal Article)

All current vaccines for COVID-19 utilize ancestral SARS-CoV-2 spike with the goal of generating protective neutralizing antibodies. The recent emergence and rapid spread of several SARS-CoV-2 variants carrying multiple spike mutations raise concerns about possible immune escape. One variant, first identified in the United Kingdom (B.1.1.7, also called 20I/501Y.V1), contains eight spike mutations with potential to impact antibody therapy, vaccine efficacy, and risk of reinfection. Here, we show that B.1.1.7 remains sensitive to neutralization, albeit at moderately reduced levels (∼sim;2-fold), by serum samples from convalescent individuals and recipients of an mRNA vaccine (mRNA-1273, Moderna) and a protein nanoparticle vaccine (NVX-CoV2373, Novavax). A subset of monoclonal antibodies to the receptor binding domain (RBD) of spike are less effective against the variant, while others are largely unaffected. These findings indicate that variant B.1.1.7 is unlikely to be a major concern for current vaccines or for an increased risk of reinfection.

Full Text

Duke Authors

Cited Authors

  • Shen, X; Tang, H; McDanal, C; Wagh, K; Fischer, W; Theiler, J; Yoon, H; Li, D; Haynes, BF; Sanders, KO; Gnanakaran, S; Hengartner, N; Pajon, R; Smith, G; Glenn, GM; Korber, B; Montefiori, DC

Published Date

  • April 14, 2021

Published In

Volume / Issue

  • 29 / 4

Start / End Page

  • 529 - 539.e3

PubMed ID

  • 33705729

Pubmed Central ID

  • PMC7934674

Electronic International Standard Serial Number (EISSN)

  • 1934-6069

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2021.03.002

Language

  • eng

Conference Location

  • United States