Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model.

Journal Article (Journal Article)

Closed head injury induces cerebral oxidative stress. The efficacy of a Mn (III) porphyrin catalytic antioxidant was assessed in a mouse closed head injury model. Mice were subjected to closed head injury and treated 15 min later with an i.v. bolus of vehicle or 3 mg/kg MnTE-2-PyP5+. Aconitase activity, Fluoro-Jade staining, glial fibrillary acidic protein immunoreactivity, and rotarod falling latencies were measured. Closed head injury altered all variables. MnTE-2-PyP5+ had no effect on any variable with the exception of attenuation of aconitase inactivation at 2 h post-closed head injury. In a second experiment, mice received 3 mg/kg or 6 mg/kg MnTE-2-PyP5+ or vehicle i.v. 15 min post-closed head injury. Rotarod and Morris water maze latencies were measured. Closed head injury altered performance in both tests. No statistically significant effect of MnTE-2-PyP5+ was observed. We conclude that single dose MnTE-2-PyP5+ does not alter outcome in this mouse closed head injury model.

Full Text

Duke Authors

Cited Authors

  • Leinenweber, SB; Sheng, H; Lynch, JR; Wang, H; Batinić-Haberle, I; Laskowitz, DT; Crapo, JD; Pearlstein, RD; Warner, DS

Published Date

  • February 15, 2006

Published In

Volume / Issue

  • 531 / 1-3

Start / End Page

  • 126 - 132

PubMed ID

  • 16455070

International Standard Serial Number (ISSN)

  • 0014-2999

Digital Object Identifier (DOI)

  • 10.1016/j.ejphar.2005.12.031


  • eng

Conference Location

  • Netherlands