Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model.
Journal Article (Journal Article)
Closed head injury induces cerebral oxidative stress. The efficacy of a Mn (III) porphyrin catalytic antioxidant was assessed in a mouse closed head injury model. Mice were subjected to closed head injury and treated 15 min later with an i.v. bolus of vehicle or 3 mg/kg MnTE-2-PyP5+. Aconitase activity, Fluoro-Jade staining, glial fibrillary acidic protein immunoreactivity, and rotarod falling latencies were measured. Closed head injury altered all variables. MnTE-2-PyP5+ had no effect on any variable with the exception of attenuation of aconitase inactivation at 2 h post-closed head injury. In a second experiment, mice received 3 mg/kg or 6 mg/kg MnTE-2-PyP5+ or vehicle i.v. 15 min post-closed head injury. Rotarod and Morris water maze latencies were measured. Closed head injury altered performance in both tests. No statistically significant effect of MnTE-2-PyP5+ was observed. We conclude that single dose MnTE-2-PyP5+ does not alter outcome in this mouse closed head injury model.
Full Text
Duke Authors
Cited Authors
- Leinenweber, SB; Sheng, H; Lynch, JR; Wang, H; Batinić-Haberle, I; Laskowitz, DT; Crapo, JD; Pearlstein, RD; Warner, DS
Published Date
- February 15, 2006
Published In
Volume / Issue
- 531 / 1-3
Start / End Page
- 126 - 132
PubMed ID
- 16455070
International Standard Serial Number (ISSN)
- 0014-2999
Digital Object Identifier (DOI)
- 10.1016/j.ejphar.2005.12.031
Language
- eng
Conference Location
- Netherlands