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Cumulative index of health disorders as an indicator of aging-associated processes in the elderly: results from analyses of the National Long Term Care Survey.

Publication ,  Journal Article
Kulminski, A; Yashin, A; Arbeev, K; Akushevich, I; Ukraintseva, S; Land, K; Manton, K
Published in: Mechanisms of ageing and development
March 2007

We employ an approach based on the elaborated frailty index (FI), which is capable of taking into account variables with mild effect on the aging, health and survival outcomes, and investigate the connections between the FI, chronological age and the aging-associated outcomes in the elderly.Cross-sectional analysis of pooled data from the National Long Term Care Survey (NLTCS) assessing health and functioning of the U.S. elderly in 1982, 1984, 1989, 1994, and 1999.Distributions of frequency, residual life span, mortality rate, and relative risk of death are remarkably similar over age and FI. Coefficients of correlation between FI and age are low both for males (0.127, p<.01) and females (0.221, p<.01). The FI-specific age patterns show deceleration at advanced ages. The FI can provide order of magnitude better resolution in estimating mean remaining life span compared to age. Males have smaller FI than females while males' mortality risks are higher. For short-time horizons, the FI and age are largely independently associated with mortality risks.The FI: (i) can be considered as an adequate sex-specific indicator of the aging-associated processes in the elderly, (ii) can characterize these processes independently of age, and (iii) is a better characteristic of the aging phenotype than chronological age.

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Published In

Mechanisms of ageing and development

DOI

EISSN

1872-6216

ISSN

0047-6374

Publication Date

March 2007

Volume

128

Issue

3

Start / End Page

250 / 258

Related Subject Headings

  • United States
  • Surveys and Questionnaires
  • Sex Factors
  • Risk
  • Proportional Hazards Models
  • Mortality
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
 

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ICMJE
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Kulminski, A., Yashin, A., Arbeev, K., Akushevich, I., Ukraintseva, S., Land, K., & Manton, K. (2007). Cumulative index of health disorders as an indicator of aging-associated processes in the elderly: results from analyses of the National Long Term Care Survey. Mechanisms of Ageing and Development, 128(3), 250–258. https://doi.org/10.1016/j.mad.2006.12.004
Kulminski, A., A. Yashin, K. Arbeev, I. Akushevich, S. Ukraintseva, K. Land, and K. Manton. “Cumulative index of health disorders as an indicator of aging-associated processes in the elderly: results from analyses of the National Long Term Care Survey.Mechanisms of Ageing and Development 128, no. 3 (March 2007): 250–58. https://doi.org/10.1016/j.mad.2006.12.004.
Kulminski A, Yashin A, Arbeev K, Akushevich I, Ukraintseva S, Land K, et al. Cumulative index of health disorders as an indicator of aging-associated processes in the elderly: results from analyses of the National Long Term Care Survey. Mechanisms of ageing and development. 2007 Mar;128(3):250–8.
Kulminski, A., et al. “Cumulative index of health disorders as an indicator of aging-associated processes in the elderly: results from analyses of the National Long Term Care Survey.Mechanisms of Ageing and Development, vol. 128, no. 3, Mar. 2007, pp. 250–58. Epmc, doi:10.1016/j.mad.2006.12.004.
Kulminski A, Yashin A, Arbeev K, Akushevich I, Ukraintseva S, Land K, Manton K. Cumulative index of health disorders as an indicator of aging-associated processes in the elderly: results from analyses of the National Long Term Care Survey. Mechanisms of ageing and development. 2007 Mar;128(3):250–258.
Journal cover image

Published In

Mechanisms of ageing and development

DOI

EISSN

1872-6216

ISSN

0047-6374

Publication Date

March 2007

Volume

128

Issue

3

Start / End Page

250 / 258

Related Subject Headings

  • United States
  • Surveys and Questionnaires
  • Sex Factors
  • Risk
  • Proportional Hazards Models
  • Mortality
  • Middle Aged
  • Male
  • Logistic Models
  • Humans