Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.

Journal Article (Journal Article)

The Gln(27)Glu polymorphism but not the Arg(16)Gly polymorphism of the beta2-adrenergic receptor (ADRB2) gene appears to be associated with a broad range of aging-associated phenotypes, including cancers at different sites, myocardial infarction (MI), intermittent claudication (IC), and overall/healthy longevity in the Framingham Heart Study Offspring cohort. The Gln(27)Gln genotype increases risks of cancer, MI and IC, whereas the Glu(27) allele or, equivalently, the Gly(16)Glu(27) haplotype tends to be protective against these diseases. Genetic associations with longevity are of opposite nature at young-old and oldest-old ages highlighting the phenomenon of antagonistic pleiotropy. The mechanism of antagonistic pleiotropy is associated with an evolutionary-driven advantage of carriers of a derived Gln(27) allele at younger ages and their survival disadvantage at older ages as a result of increased risks of cancer, MI and IC. The ADRB2 gene can play an important systemic role in healthy aging in evolutionary context that warrants exploration in other populations.

Full Text

Duke Authors

Cited Authors

  • Kulminski, AM; Culminskaya, I; Ukraintseva, SV; Arbeev, KG; Land, KC; Yashin, AI

Published Date

  • May 2010

Published In

Volume / Issue

  • 131 / 5

Start / End Page

  • 338 - 345

PubMed ID

  • 20399803

Pubmed Central ID

  • PMC2895994

Electronic International Standard Serial Number (EISSN)

  • 1872-6216

International Standard Serial Number (ISSN)

  • 0047-6374

Digital Object Identifier (DOI)

  • 10.1016/j.mad.2010.04.001


  • eng