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Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens.

Publication ,  Journal Article
Kulminski, AM; Molleman, F; Culminskaya, IV; Arbeev, KG; Ukraintseva, SV; Carey, JR; Yashin, AI
Published in: Experimental gerontology
November 2009

We use unique experimental data on daily reproduction and survival of individual fruit flies from eight cohorts eclosed at different dates in 2004 and 2005 who were treated with varying proportions of sugar and yeast and subject to different caloric restrictions (CR). We investigate the relationship between eclosion date and longevity across diets and reproduction in Anastrepha ludens. We show that eclosion date can be associated with uncontrolled external or internal factor(s) which can modulate longevity of males and females independently of diet and reproduction to the extent similar to the effect of diet on longevity. The effect of diet manipulation on longevity is sensitive to date of eclosion with the role of CR in life extension ranging from beneficial to harmful. Interaction of date of eclosion with compositional changes of sugar and yeast but not with CR is responsible for life extension. Highly protein-enriched diets reliably maximize reproduction but not life span. Decreased longevity of flies treated with high-protein diets may be associated with harmful consequences of protein ingestion but is unlikely a result of high reproduction rates. We present evidence for the presence of two frailty-sensitive weakly interacting mechanisms of longevity in female flies associated with differences in predisposed fitness.

Duke Scholars

Published In

Experimental gerontology

DOI

EISSN

1873-6815

ISSN

0531-5565

Publication Date

November 2009

Volume

44

Issue

11

Start / End Page

718 / 726

Related Subject Headings

  • Yeasts
  • Tephritidae
  • Male
  • Longevity
  • Gerontology
  • Fertility
  • Female
  • Diet
  • Caloric Restriction
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kulminski, A. M., Molleman, F., Culminskaya, I. V., Arbeev, K. G., Ukraintseva, S. V., Carey, J. R., & Yashin, A. I. (2009). Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens. Experimental Gerontology, 44(11), 718–726. https://doi.org/10.1016/j.exger.2009.08.007
Kulminski, Alexander M., Freerk Molleman, Irina V. Culminskaya, Konstantin G. Arbeev, Svetlana V. Ukraintseva, James R. Carey, and Anatoli I. Yashin. “Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens.Experimental Gerontology 44, no. 11 (November 2009): 718–26. https://doi.org/10.1016/j.exger.2009.08.007.
Kulminski AM, Molleman F, Culminskaya IV, Arbeev KG, Ukraintseva SV, Carey JR, et al. Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens. Experimental gerontology. 2009 Nov;44(11):718–26.
Kulminski, Alexander M., et al. “Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens.Experimental Gerontology, vol. 44, no. 11, Nov. 2009, pp. 718–26. Epmc, doi:10.1016/j.exger.2009.08.007.
Kulminski AM, Molleman F, Culminskaya IV, Arbeev KG, Ukraintseva SV, Carey JR, Yashin AI. Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens. Experimental gerontology. 2009 Nov;44(11):718–726.
Journal cover image

Published In

Experimental gerontology

DOI

EISSN

1873-6815

ISSN

0531-5565

Publication Date

November 2009

Volume

44

Issue

11

Start / End Page

718 / 726

Related Subject Headings

  • Yeasts
  • Tephritidae
  • Male
  • Longevity
  • Gerontology
  • Fertility
  • Female
  • Diet
  • Caloric Restriction
  • Animals