HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life.
Journal Article (Journal Article)
Prevention of HIV-1 transmission at mucosal surfaces will likely require durable pre-existing mucosal anti-HIV-1 antibodies (Abs). Defining the ontogeny, specificities and potentially protective nature of the initial mucosal virus-specific B-cell response will be critical for understanding how to induce protective Ab responses by vaccination. Genital fluids from patients within the earliest stages of acute HIV-1 infection (Fiebig I-VI) were examined for multiple anti-HIV specificities. Gp41 (but not gp120) Env immunoglobulin (Ig)A Abs were frequently elicited in both plasma and mucosal fluids within the first weeks of transmission. However, shortly after induction, these initial mucosal gp41 Env IgA Abs rapidly declined with a t(½) of ∼2.7 days. B-cell-activating factor belonging to the TNF family (BAFF) was elevated immediately preceding the appearance of gp41 Abs, likely contributing to an initial T-independent Ab response. HIV-1 transmission frequently elicits mucosal HIV-1 envelope-specific IgA responses targeted to gp41 that have a short half-life.
Full Text
Duke Authors
- Haynes, Barton Ford
- Montefiori, David Charles
- Moody, Michael Anthony
- Tomaras, Georgia Doris
- Weinhold, Kent James
Cited Authors
- Yates, NL; Stacey, AR; Nolen, TL; Vandergrift, NA; Moody, MA; Montefiori, DC; Weinhold, KJ; Blattner, WA; Borrow, P; Shattock, R; Cohen, MS; Haynes, BF; Tomaras, GD
Published Date
- July 2013
Published In
Volume / Issue
- 6 / 4
Start / End Page
- 692 - 703
PubMed ID
- 23299618
Pubmed Central ID
- PMC3663876
Electronic International Standard Serial Number (EISSN)
- 1935-3456
Digital Object Identifier (DOI)
- 10.1038/mi.2012.107
Language
- eng
Conference Location
- United States