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HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life.

Publication ,  Journal Article
Yates, NL; Stacey, AR; Nolen, TL; Vandergrift, NA; Moody, MA; Montefiori, DC; Weinhold, KJ; Blattner, WA; Borrow, P; Shattock, R; Cohen, MS ...
Published in: Mucosal Immunol
July 2013

Prevention of HIV-1 transmission at mucosal surfaces will likely require durable pre-existing mucosal anti-HIV-1 antibodies (Abs). Defining the ontogeny, specificities and potentially protective nature of the initial mucosal virus-specific B-cell response will be critical for understanding how to induce protective Ab responses by vaccination. Genital fluids from patients within the earliest stages of acute HIV-1 infection (Fiebig I-VI) were examined for multiple anti-HIV specificities. Gp41 (but not gp120) Env immunoglobulin (Ig)A Abs were frequently elicited in both plasma and mucosal fluids within the first weeks of transmission. However, shortly after induction, these initial mucosal gp41 Env IgA Abs rapidly declined with a t(½) of ∼2.7 days. B-cell-activating factor belonging to the TNF family (BAFF) was elevated immediately preceding the appearance of gp41 Abs, likely contributing to an initial T-independent Ab response. HIV-1 transmission frequently elicits mucosal HIV-1 envelope-specific IgA responses targeted to gp41 that have a short half-life.

Duke Scholars

Published In

Mucosal Immunol

DOI

EISSN

1935-3456

Publication Date

July 2013

Volume

6

Issue

4

Start / End Page

692 / 703

Location

United States

Related Subject Headings

  • Time Factors
  • Male
  • Lymphocyte Activation
  • Immunology
  • Immunoglobulin G
  • Immunoglobulin A
  • Immunity, Mucosal
  • Humans
  • HIV-1
  • HIV Infections
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yates, N. L., Stacey, A. R., Nolen, T. L., Vandergrift, N. A., Moody, M. A., Montefiori, D. C., … Tomaras, G. D. (2013). HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life. Mucosal Immunol, 6(4), 692–703. https://doi.org/10.1038/mi.2012.107
Yates, N. L., A. R. Stacey, T. L. Nolen, N. A. Vandergrift, M. A. Moody, D. C. Montefiori, K. J. Weinhold, et al. “HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life.Mucosal Immunol 6, no. 4 (July 2013): 692–703. https://doi.org/10.1038/mi.2012.107.
Yates NL, Stacey AR, Nolen TL, Vandergrift NA, Moody MA, Montefiori DC, et al. HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life. Mucosal Immunol. 2013 Jul;6(4):692–703.
Yates, N. L., et al. “HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life.Mucosal Immunol, vol. 6, no. 4, July 2013, pp. 692–703. Pubmed, doi:10.1038/mi.2012.107.
Yates NL, Stacey AR, Nolen TL, Vandergrift NA, Moody MA, Montefiori DC, Weinhold KJ, Blattner WA, Borrow P, Shattock R, Cohen MS, Haynes BF, Tomaras GD. HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life. Mucosal Immunol. 2013 Jul;6(4):692–703.

Published In

Mucosal Immunol

DOI

EISSN

1935-3456

Publication Date

July 2013

Volume

6

Issue

4

Start / End Page

692 / 703

Location

United States

Related Subject Headings

  • Time Factors
  • Male
  • Lymphocyte Activation
  • Immunology
  • Immunoglobulin G
  • Immunoglobulin A
  • Immunity, Mucosal
  • Humans
  • HIV-1
  • HIV Infections