A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults.

Journal Article (Journal Article)

Relative to diets enriched in palmitic acid (PA), diets rich in oleic acid (OA) are associated with reduced risk of type 2 diabetes. To gain insight into mechanisms underlying these observations, we applied comprehensive lipidomic profiling to specimens collected from healthy adults enrolled in a randomized, crossover trial comparing a high-PA diet to a low-PA/high-OA (HOA) diet. Effects on insulin sensitivity (SI) and disposition index (DI) were assessed by intravenous glucose tolerance testing. In women, but not men, SI and DI were higher during HOA. The effect of HOA on SI correlated positively with physical fitness upon enrollment. Principal components analysis of either fasted or fed-state metabolites identified one factor affected by diet and heavily weighted by the PA/OA ratio of serum and muscle lipids. In women, this factor correlated inversely with SI in the fasted and fed states. Medium-chain acylcarnitines emerged as strong negative correlates of SI, and the HOA diet was accompanied by lower serum and muscle ceramide concentrations and reductions in molecular biomarkers of inflammatory and oxidative stress. This study provides evidence that the dietary PA/OA ratio impacts diabetes risk in women.

Full Text

Duke Authors

Cited Authors

  • Kien, CL; Bunn, JY; Poynter, ME; Stevens, R; Bain, J; Ikayeva, O; Fukagawa, NK; Champagne, CM; Crain, KI; Koves, TR; Muoio, DM

Published Date

  • April 2013

Published In

Volume / Issue

  • 62 / 4

Start / End Page

  • 1054 - 1063

PubMed ID

  • 23238293

Pubmed Central ID

  • PMC3609566

Electronic International Standard Serial Number (EISSN)

  • 1939-327X

Digital Object Identifier (DOI)

  • 10.2337/db12-0363


  • eng

Conference Location

  • United States