Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity.
Publication
, Journal Article
Liu, P; Williams, LD; Shen, X; Bonsignori, M; Vandergrift, NA; Overman, RG; Moody, MA; Liao, H-X; Stieh, DJ; McCotter, KL; French, AL ...
Published in: J Virol
May 2014
Antibody capacity to recognize infectious virus is a prerequisite of many antiviral functions. We determined the infectious virion capture index (IVCI) of different antibody specificities. Whereas broadly neutralizing antibodies (bNAbs), except for an MPER bNAb, selectively captured infectious virions, non-bNAbs and mucosal human immunodeficiency virus type 1 (HIV-1)-positive IgG captured subsets of both infectious and noninfectious virions. Infectious virion capture was additive with a mixture of antibodies, providing proof of concept for vaccine-induced antibodies that together have improved capacity to recognize infectious virions.
Duke Scholars
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Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
May 2014
Volume
88
Issue
9
Start / End Page
5165 / 5170
Location
United States
Related Subject Headings
- env Gene Products, Human Immunodeficiency Virus
- Virology
- Immunoglobulin G
- HIV-1
- HIV Antibodies
- Female
- Antibody Specificity
- Antibodies, Neutralizing
- Antibodies, Monoclonal
- Animals
Citation
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Chicago
ICMJE
MLA
NLM
Liu, P., Williams, L. D., Shen, X., Bonsignori, M., Vandergrift, N. A., Overman, R. G., … Tomaras, G. D. (2014). Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity. J Virol, 88(9), 5165–5170. https://doi.org/10.1128/JVI.03765-13
Liu, Pinghuang, Latonya D. Williams, Xiaoying Shen, Mattia Bonsignori, Nathan A. Vandergrift, R Glenn Overman, M Anthony Moody, et al. “Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity.” J Virol 88, no. 9 (May 2014): 5165–70. https://doi.org/10.1128/JVI.03765-13.
Liu P, Williams LD, Shen X, Bonsignori M, Vandergrift NA, Overman RG, et al. Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity. J Virol. 2014 May;88(9):5165–70.
Liu, Pinghuang, et al. “Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity.” J Virol, vol. 88, no. 9, May 2014, pp. 5165–70. Pubmed, doi:10.1128/JVI.03765-13.
Liu P, Williams LD, Shen X, Bonsignori M, Vandergrift NA, Overman RG, Moody MA, Liao H-X, Stieh DJ, McCotter KL, French AL, Hope TJ, Shattock R, Haynes BF, Tomaras GD. Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity. J Virol. 2014 May;88(9):5165–5170.
Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
May 2014
Volume
88
Issue
9
Start / End Page
5165 / 5170
Location
United States
Related Subject Headings
- env Gene Products, Human Immunodeficiency Virus
- Virology
- Immunoglobulin G
- HIV-1
- HIV Antibodies
- Female
- Antibody Specificity
- Antibodies, Neutralizing
- Antibodies, Monoclonal
- Animals