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Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease.

Publication ,  Journal Article
Dahhan, T; Kaushik, SS; He, M; Mammarappallil, JG; Tapson, VF; McAdams, HP; Sporn, TA; Driehuys, B; Rajagopal, S
Published in: Pulm Circ
March 2016

The diagnosis of pulmonary vascular disease (PVD) is usually based on hemodynamic and/or clinical criteria. Noninvasive imaging of the heart and proximal vasculature can also provide useful information. An alternate approach to such criteria in the diagnosis of PVD is to image the vascular abnormalities in the lungs themselves. Hyperpolarized (HP) (129)Xe magnetic resonance imaging (MRI) is a novel technique for assessing abnormalities in ventilation and gas exchange in the lungs. We applied this technique to two patients for whom there was clinical suspicion of PVD. Two patients who had significant hypoxemia and dyspnea with no significant abnormalities on computed tomography imaging or ventilation-perfusion scan and only mild or borderline pulmonary arterial hypertension at catheterization were evaluated. They underwent HP (129)Xe imaging and subsequently had tissue diagnosis obtained from lung pathology. In both patients, HP (129)Xe imaging demonstrated normal ventilation but markedly decreased gas transfer to red blood cells with focal defects on imaging, a pattern distinct from those previously described for idiopathic pulmonary fibrosis or obstructive lung disease. Pathology on both patients later demonstrated severe PVD. These findings suggest that HP (129)Xe MRI may be useful in the diagnosis of PVD and monitoring response to therapy. Further studies are required to determine its sensitivity and specificity in these settings.

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Published In

Pulm Circ

DOI

ISSN

2045-8932

Publication Date

March 2016

Volume

6

Issue

1

Start / End Page

126 / 131

Location

United States

Related Subject Headings

  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

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Dahhan, T., Kaushik, S. S., He, M., Mammarappallil, J. G., Tapson, V. F., McAdams, H. P., … Rajagopal, S. (2016). Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease. Pulm Circ, 6(1), 126–131. https://doi.org/10.1086/685110
Dahhan, Talal, Shiv S. Kaushik, Mu He, Joseph G. Mammarappallil, Victor F. Tapson, Holman P. McAdams, Thomas A. Sporn, Bastiaan Driehuys, and Sudarshan Rajagopal. “Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease.Pulm Circ 6, no. 1 (March 2016): 126–31. https://doi.org/10.1086/685110.
Dahhan T, Kaushik SS, He M, Mammarappallil JG, Tapson VF, McAdams HP, et al. Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease. Pulm Circ. 2016 Mar;6(1):126–31.
Dahhan, Talal, et al. “Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease.Pulm Circ, vol. 6, no. 1, Mar. 2016, pp. 126–31. Pubmed, doi:10.1086/685110.
Dahhan T, Kaushik SS, He M, Mammarappallil JG, Tapson VF, McAdams HP, Sporn TA, Driehuys B, Rajagopal S. Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease. Pulm Circ. 2016 Mar;6(1):126–131.
Journal cover image

Published In

Pulm Circ

DOI

ISSN

2045-8932

Publication Date

March 2016

Volume

6

Issue

1

Start / End Page

126 / 131

Location

United States

Related Subject Headings

  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology