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Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI.

Publication ,  Journal Article
Wang, Z; Robertson, SH; Wang, J; He, M; Virgincar, RS; Schrank, GM; Bier, EA; Rajagopal, S; Huang, YC; O'Riordan, TG; Rackley, CR; McAdams, HP ...
Published in: Med Phys
June 2017

PURPOSE: Hyperpolarized 129 Xe magnetic resonance imaging (MRI) using Dixon-based decomposition enables single-breath imaging of 129 Xe in the airspaces, interstitial barrier tissues, and red blood cells (RBCs). However, methods to quantitatively visualize information from these images of pulmonary gas transfer are lacking. Here, we introduce a novel method to transform these data into quantitative maps of pulmonary ventilation, and 129 Xe gas transfer to barrier and RBC compartments. METHODS: A total of 13 healthy subjects and 12 idiopathic pulmonary fibrosis (IPF) subjects underwent thoracic 1 H MRI and hyperpolarized 129 Xe MRI with one-point Dixon decomposition to obtain images of 129 Xe in airspaces, barrier and red blood cells (RBCs). 129 Xe images were processed into quantitative binning maps of all three compartments using thresholds based on the mean and standard deviations of distributions derived from the healthy reference cohort. Binning maps were analyzed to derive quantitative measures of ventilation, barrier uptake, and RBC transfer. This method was also used to illustrate different ventilation and gas transfer patterns in a patient with emphysema and one with pulmonary arterial hypertension (PAH). RESULTS: In the healthy reference cohort, the mean normalized signals were 0.51 ± 0.19 for ventilation, 4.9 ± 1.5 x 10-3 for barrier uptake and 2.6 ± 1.0 × 10-3 for RBC (transfer). In IPF patients, ventilation was similarly homogenous to healthy subjects, although shifted toward slightly lower values (0.43 ± 0.19). However, mean barrier uptake in IPF patients was nearly 2× higher than in healthy subjects, with 47% of voxels classified as high, compared to 3% in healthy controls. Moreover, in IPF, RBC transfer was reduced, mainly in the basal lung with 41% of voxels classified as low. In healthy volunteers, only 15% of RBC transfer was classified as low and these voxels were typically in the anterior, gravitationally nondependent lung. CONCLUSIONS: This study demonstrates a straightforward means to generate semiquantitative binning maps depicting 129 Xe ventilation and gas transfer to barrier and RBC compartments. These initial results suggest that the method could be valuable for characterizing both normal physiology and pathophysiology associated with a wide range of pulmonary disorders.

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Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2017

Volume

44

Issue

6

Start / End Page

2415 / 2428

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Pulmonary Ventilation
  • Pulmonary Emphysema
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Lung
  • Humans
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
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ICMJE
MLA
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Wang, Z., Robertson, S. H., Wang, J., He, M., Virgincar, R. S., Schrank, G. M., … Driehuys, B. (2017). Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI. Med Phys, 44(6), 2415–2428. https://doi.org/10.1002/mp.12264
Wang, Ziyi, Scott Haile Robertson, Jennifer Wang, Mu He, Rohan S. Virgincar, Geoffry M. Schrank, Elianna A. Bier, et al. “Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI.Med Phys 44, no. 6 (June 2017): 2415–28. https://doi.org/10.1002/mp.12264.
Wang Z, Robertson SH, Wang J, He M, Virgincar RS, Schrank GM, et al. Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI. Med Phys. 2017 Jun;44(6):2415–28.
Wang, Ziyi, et al. “Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI.Med Phys, vol. 44, no. 6, June 2017, pp. 2415–28. Pubmed, doi:10.1002/mp.12264.
Wang Z, Robertson SH, Wang J, He M, Virgincar RS, Schrank GM, Bier EA, Rajagopal S, Huang YC, O’Riordan TG, Rackley CR, McAdams HP, Driehuys B. Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI. Med Phys. 2017 Jun;44(6):2415–2428.

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2017

Volume

44

Issue

6

Start / End Page

2415 / 2428

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Pulmonary Ventilation
  • Pulmonary Emphysema
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Lung
  • Humans
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis