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Evaluation of inner retinal layers as biomarkers in mild cognitive impairment to moderate Alzheimer's disease.

Publication ,  Journal Article
Lad, EM; Mukherjee, D; Stinnett, SS; Cousins, SW; Potter, GG; Burke, JR; Farsiu, S; Whitson, HE
Published in: PLoS One
2018

Inner retina in Alzheimer's Disease (AD) may experience neuroinflammation resulting in atrophy. The objective of our study was to determine whether retinal GCIPL (ganglion cell-inner plexiform layer) or nerve fiber layer (NFL) thickness may serve as noninvasive biomarkers to diagnose AD. This cross-sectional case-control study enrolled 15 mild cognitive impairment (MCI) patients, 15 mild-moderate AD patients, and 18 cognitively normal adults. NFL and GCIPL thicknesses on optical coherence tomography (OCT) were measured using Duke Optical Coherence Tomography Retinal Analysis Program (DOCTRAP) and Spectralis software. We demonstrated that regional thicknesses of NFL or GCIPL on macular or nerve OCTs did not differ between groups. However, a multi-variate regression analysis identified macular areas with a significant thickening or thinning in NFL and GCIPL in MCI and AD patients. Our primary findings controvert previous reports of thinner NFL in moderate-to-severe AD. The areas of thickening of GCIPL and NFL in the macula adjacent to areas of thinning, as revealed by a more complex statistical model, suggest that NFL and GCIPL may undergo dynamic changes during AD progression.

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2018

Volume

13

Issue

2

Start / End Page

e0192646

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Retina
  • Middle Aged
  • Male
  • Humans
  • General Science & Technology
  • Female
  • Cognition Disorders
  • Biomarkers
  • Alzheimer Disease
 

Citation

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Lad, E. M., Mukherjee, D., Stinnett, S. S., Cousins, S. W., Potter, G. G., Burke, J. R., … Whitson, H. E. (2018). Evaluation of inner retinal layers as biomarkers in mild cognitive impairment to moderate Alzheimer's disease. PLoS One, 13(2), e0192646. https://doi.org/10.1371/journal.pone.0192646
Lad, Eleonora M., Dibyendu Mukherjee, Sandra S. Stinnett, Scott W. Cousins, Guy G. Potter, James R. Burke, Sina Farsiu, and Heather E. Whitson. “Evaluation of inner retinal layers as biomarkers in mild cognitive impairment to moderate Alzheimer's disease.PLoS One 13, no. 2 (2018): e0192646. https://doi.org/10.1371/journal.pone.0192646.
Lad EM, Mukherjee D, Stinnett SS, Cousins SW, Potter GG, Burke JR, et al. Evaluation of inner retinal layers as biomarkers in mild cognitive impairment to moderate Alzheimer's disease. PLoS One. 2018;13(2):e0192646.
Lad, Eleonora M., et al. “Evaluation of inner retinal layers as biomarkers in mild cognitive impairment to moderate Alzheimer's disease.PLoS One, vol. 13, no. 2, 2018, p. e0192646. Pubmed, doi:10.1371/journal.pone.0192646.
Lad EM, Mukherjee D, Stinnett SS, Cousins SW, Potter GG, Burke JR, Farsiu S, Whitson HE. Evaluation of inner retinal layers as biomarkers in mild cognitive impairment to moderate Alzheimer's disease. PLoS One. 2018;13(2):e0192646.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2018

Volume

13

Issue

2

Start / End Page

e0192646

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Retina
  • Middle Aged
  • Male
  • Humans
  • General Science & Technology
  • Female
  • Cognition Disorders
  • Biomarkers
  • Alzheimer Disease