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Cardiovascular Metabolomics.

Publication ,  Journal Article
McGarrah, RW; Crown, SB; Zhang, G-F; Shah, SH; Newgard, CB
Published in: Circ Res
April 27, 2018

Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics, one of the newer omics technologies, has emerged as a powerful tool for defining changes in both global and cardiac-specific metabolism that occur across a spectrum of cardiovascular disease states. Findings from metabolomics studies have contributed to better understanding of the metabolic changes that occur in heart failure and ischemic heart disease and have identified new cardiovascular disease biomarkers. As technologies advance, the metabolomics field continues to evolve rapidly. In this review, we will discuss the current state of metabolomics technologies, including consideration of various metabolomics platforms and elements of study design; the emerging utility of stable isotopes for metabolic flux studies; and the use of metabolomics to better understand specific cardiovascular diseases, with an emphasis on recent advances in the field.

Duke Scholars

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Published In

Circ Res

DOI

EISSN

1524-4571

Publication Date

April 27, 2018

Volume

122

Issue

9

Start / End Page

1238 / 1258

Location

United States

Related Subject Headings

  • Specimen Handling
  • Risk Assessment
  • Research Design
  • Proteome
  • Nuclear Magnetic Resonance, Biomolecular
  • Myocardium
  • Mice
  • Metabolomics
  • Mass Spectrometry
  • Isotopes
 

Citation

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McGarrah, R. W., Crown, S. B., Zhang, G.-F., Shah, S. H., & Newgard, C. B. (2018). Cardiovascular Metabolomics. Circ Res, 122(9), 1238–1258. https://doi.org/10.1161/CIRCRESAHA.117.311002
McGarrah, Robert W., Scott B. Crown, Guo-Fang Zhang, Svati H. Shah, and Christopher B. Newgard. “Cardiovascular Metabolomics.Circ Res 122, no. 9 (April 27, 2018): 1238–58. https://doi.org/10.1161/CIRCRESAHA.117.311002.
McGarrah RW, Crown SB, Zhang G-F, Shah SH, Newgard CB. Cardiovascular Metabolomics. Circ Res. 2018 Apr 27;122(9):1238–58.
McGarrah, Robert W., et al. “Cardiovascular Metabolomics.Circ Res, vol. 122, no. 9, Apr. 2018, pp. 1238–58. Pubmed, doi:10.1161/CIRCRESAHA.117.311002.
McGarrah RW, Crown SB, Zhang G-F, Shah SH, Newgard CB. Cardiovascular Metabolomics. Circ Res. 2018 Apr 27;122(9):1238–1258.

Published In

Circ Res

DOI

EISSN

1524-4571

Publication Date

April 27, 2018

Volume

122

Issue

9

Start / End Page

1238 / 1258

Location

United States

Related Subject Headings

  • Specimen Handling
  • Risk Assessment
  • Research Design
  • Proteome
  • Nuclear Magnetic Resonance, Biomolecular
  • Myocardium
  • Mice
  • Metabolomics
  • Mass Spectrometry
  • Isotopes