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Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle.

Publication ,  Journal Article
Orenduff, MC; Coleman, MF; Glenny, EM; Huffman, KM; Rezeli, ET; Bareja, A; Pieper, CF; Kraus, VB; Hursting, SD
Published in: Exp Gerontol
August 2022

Aging is a multifactorial process associated with progressive degradation of physiological integrity and function. One of the greatest factors contributing to the deleterious effects of aging is the decline of functional ability due to loss of muscle mass, strength, and function, a condition termed sarcopenia. Calorie restriction (CR) has consistently been shown to extend lifespan and delay the onset and progression of various age-related diseases, including sarcopenia. Additional anti-aging interventions that are receiving scientific attention are CR mimetics. Of these pharmacological compounds, rapamycin has shown similar CR-related longevity benefits without the need for diet restrictions. To investigate the potential role of rapamycin as an anti-sarcopenic alternative to CR, we conducted a study in male and female C57BL/6 J mice to assess the effects of rapamycin on age-related gene expression changes in skeletal muscle associated with loss of muscle mass, strength, and function, relative to control. We hypothesize that the effects of rapamycin will closely align with CR with respect to physical function and molecular indices associated with muscle quality. Our results indicate CR and rapamycin provide partial protection against age-related decline in muscle, while engaging uniquely different molecular pathways in skeletal muscle. Our preclinical findings of the therapeutic potential of rapamycin or a CR regimen on geroprotective benefits in muscle should be extended to translational studies towards the development of effective strategies for the prevention and management of sarcopenia.

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Published In

Exp Gerontol

DOI

EISSN

1873-6815

Publication Date

August 2022

Volume

165

Start / End Page

111841

Location

England

Related Subject Headings

  • Sirolimus
  • Sarcopenia
  • Muscle, Skeletal
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Gerontology
  • Female
  • Caloric Restriction
  • Animals
 

Citation

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MLA
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Orenduff, M. C., Coleman, M. F., Glenny, E. M., Huffman, K. M., Rezeli, E. T., Bareja, A., … Hursting, S. D. (2022). Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle. Exp Gerontol, 165, 111841. https://doi.org/10.1016/j.exger.2022.111841
Orenduff, Melissa C., Michael F. Coleman, Elaine M. Glenny, Kim M. Huffman, Erika T. Rezeli, Akshay Bareja, Carl F. Pieper, Virginia B. Kraus, and Stephen D. Hursting. “Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle.Exp Gerontol 165 (August 2022): 111841. https://doi.org/10.1016/j.exger.2022.111841.
Orenduff MC, Coleman MF, Glenny EM, Huffman KM, Rezeli ET, Bareja A, et al. Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle. Exp Gerontol. 2022 Aug;165:111841.
Orenduff, Melissa C., et al. “Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle.Exp Gerontol, vol. 165, Aug. 2022, p. 111841. Pubmed, doi:10.1016/j.exger.2022.111841.
Orenduff MC, Coleman MF, Glenny EM, Huffman KM, Rezeli ET, Bareja A, Pieper CF, Kraus VB, Hursting SD. Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle. Exp Gerontol. 2022 Aug;165:111841.
Journal cover image

Published In

Exp Gerontol

DOI

EISSN

1873-6815

Publication Date

August 2022

Volume

165

Start / End Page

111841

Location

England

Related Subject Headings

  • Sirolimus
  • Sarcopenia
  • Muscle, Skeletal
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Gerontology
  • Female
  • Caloric Restriction
  • Animals