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Neuroimaging and immunological features of neurocognitive function related to substance use in people with HIV.

Publication ,  Journal Article
Murdoch, DM; Barfield, R; Chan, C; Towe, SL; Bell, RP; Volkheimer, A; Choe, J; Hall, SA; Berger, M; Xie, J; Meade, CS
Published in: J Neurovirol
February 2023

This study sought to identify neuroimaging and immunological factors associated with substance use and that contribute to neurocognitive impairment (NCI) in people with HIV (PWH). We performed cross-sectional immunological phenotyping, neuroimaging, and neurocognitive testing on virally suppressed PWH in four substance groups: cocaine only users (COC), marijuana only users (MJ), dual users (Dual), and Non-users. Participants completed substance use assessments, multimodal MRI brain scan, neuropsychological testing, and blood and CSF sampling. We employed a two-stage analysis of 305 possible biomarkers of cognitive function associated with substance use. Feature reduction (Kruskal Wallis p-value < 0.05) identified 53 biomarkers associated with substance use (22 MRI and 31 immunological) for model inclusion along with clinical and demographic variables. We employed eXtreme Gradient Boosting (XGBoost) with these markers to predict cognitive function (global T-score). SHapley Additive exPlanations (SHAP) values were calculated to rank features for impact on model output and NCI. Participants were 110 PWH with sustained HIV viral suppression (33 MJ, 12 COC, 22 Dual, and 43 Non-users). The ten highest ranking biomarkers for predicting global T-score were 4 neuroimaging biomarkers including functional connectivity, gray matter volume, and white matter integrity; 5 soluble biomarkers (plasma glycine, alanine, lyso-phosphatidylcholine (lysoPC) aC17.0, hydroxy-sphingomyelin (SM.OH) C14.1, and phosphatidylcholinediacyl (PC aa) C28.1); and 1 clinical variable (nadir CD4 count). The results of our machine learning model suggest that substance use may indirectly contribute to NCI in PWH through both metabolomic and neuropathological mechanisms.

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Published In

J Neurovirol

DOI

EISSN

1538-2443

Publication Date

February 2023

Volume

29

Issue

1

Start / End Page

78 / 93

Location

United States

Related Subject Headings

  • Virology
  • Substance-Related Disorders
  • Neuroimaging
  • Humans
  • HIV Infections
  • Cross-Sectional Studies
  • Cognition
  • 3209 Neurosciences
  • 3207 Medical microbiology
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Murdoch, D. M., Barfield, R., Chan, C., Towe, S. L., Bell, R. P., Volkheimer, A., … Meade, C. S. (2023). Neuroimaging and immunological features of neurocognitive function related to substance use in people with HIV. J Neurovirol, 29(1), 78–93. https://doi.org/10.1007/s13365-022-01102-2
Murdoch, David M., Richard Barfield, Cliburn Chan, Sheri L. Towe, Ryan P. Bell, Alicia Volkheimer, Joyce Choe, et al. “Neuroimaging and immunological features of neurocognitive function related to substance use in people with HIV.J Neurovirol 29, no. 1 (February 2023): 78–93. https://doi.org/10.1007/s13365-022-01102-2.
Murdoch DM, Barfield R, Chan C, Towe SL, Bell RP, Volkheimer A, et al. Neuroimaging and immunological features of neurocognitive function related to substance use in people with HIV. J Neurovirol. 2023 Feb;29(1):78–93.
Murdoch, David M., et al. “Neuroimaging and immunological features of neurocognitive function related to substance use in people with HIV.J Neurovirol, vol. 29, no. 1, Feb. 2023, pp. 78–93. Pubmed, doi:10.1007/s13365-022-01102-2.
Murdoch DM, Barfield R, Chan C, Towe SL, Bell RP, Volkheimer A, Choe J, Hall SA, Berger M, Xie J, Meade CS. Neuroimaging and immunological features of neurocognitive function related to substance use in people with HIV. J Neurovirol. 2023 Feb;29(1):78–93.
Journal cover image

Published In

J Neurovirol

DOI

EISSN

1538-2443

Publication Date

February 2023

Volume

29

Issue

1

Start / End Page

78 / 93

Location

United States

Related Subject Headings

  • Virology
  • Substance-Related Disorders
  • Neuroimaging
  • Humans
  • HIV Infections
  • Cross-Sectional Studies
  • Cognition
  • 3209 Neurosciences
  • 3207 Medical microbiology
  • 3202 Clinical sciences