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The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis.

Publication ,  Journal Article
Coppock, JA; McNulty, AL; Porter Starr, KN; Holt, AG; Borack, MS; Kosinski, AS; Collins, AT; Bales, CW; DeFrate, LE
Published in: Osteoarthr Cartil Open
September 2023

OBJECTIVE: To examine the effects of a 6-month weight loss intervention on physical function, inflammatory biomarkers, and metabolic biomarkers in both those with and without osteoarthritis (OA). DESIGN: 59 individuals ≥60 years old with obesity and a functional impairment were enrolled into this IRB approved clinical trial and randomized into one of two 6-month weight loss arms: a higher protein hypocaloric diet or a standard protein hypocaloric diet. All participants were prescribed individualized 500-kcal daily-deficit diets, with a goal of 10% weight loss. Additionally, participants participated in three, low-intensity, exercise sessions per week. Physical function, serum biomarkers and body composition data were assessed at the baseline and 6-month timepoints. Statistical analyses assessed the relationships between biomarkers, physical function, body composition, and OA status as a result of the intervention. RESULTS: No group effects of dietary intervention were detected on any outcome measures (multiple p ​> ​0.05). During the 6-month trial, participants lost 6.2 ​± ​4.0% of their bodyweight (p ​< ​0.0001) and experienced improved physical function on the Short-Performance-Physical-Battery (p ​< ​0.0001), 8-foot-up-and-go (p ​< ​0.0001), and time to complete 10-chair-stands (p ​< ​0.0001). Adiponectin concentrations (p ​= ​0.0480) were elevated, and cartilage oligomeric matrix protein (COMP) concentrations (p ​< ​0.0001) were reduced; further analysis revealed that reductions in serum COMP concentrations were greater in OA-negative individuals. CONCLUSIONS: These results suggest that weight loss in older adults with and without OA may provide a protective effect to cartilage and OA. In particular, OA-negative individuals may be able to mitigate changes associated with OA through weight loss.

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Published In

Osteoarthr Cartil Open

DOI

EISSN

2665-9131

Publication Date

September 2023

Volume

5

Issue

3

Start / End Page

100376

Location

England

Related Subject Headings

  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Coppock, J. A., McNulty, A. L., Porter Starr, K. N., Holt, A. G., Borack, M. S., Kosinski, A. S., … DeFrate, L. E. (2023). The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis. Osteoarthr Cartil Open, 5(3), 100376. https://doi.org/10.1016/j.ocarto.2023.100376
Coppock, James A., Amy L. McNulty, Kathryn N. Porter Starr, Abigail G. Holt, Michael S. Borack, Andrzej S. Kosinski, Amber T. Collins, Connie W. Bales, and Louis E. DeFrate. “The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis.Osteoarthr Cartil Open 5, no. 3 (September 2023): 100376. https://doi.org/10.1016/j.ocarto.2023.100376.
Coppock JA, McNulty AL, Porter Starr KN, Holt AG, Borack MS, Kosinski AS, et al. The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis. Osteoarthr Cartil Open. 2023 Sep;5(3):100376.
Coppock, James A., et al. “The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis.Osteoarthr Cartil Open, vol. 5, no. 3, Sept. 2023, p. 100376. Pubmed, doi:10.1016/j.ocarto.2023.100376.
Coppock JA, McNulty AL, Porter Starr KN, Holt AG, Borack MS, Kosinski AS, Collins AT, Bales CW, DeFrate LE. The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis. Osteoarthr Cartil Open. 2023 Sep;5(3):100376.

Published In

Osteoarthr Cartil Open

DOI

EISSN

2665-9131

Publication Date

September 2023

Volume

5

Issue

3

Start / End Page

100376

Location

England

Related Subject Headings

  • 3202 Clinical sciences