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Detection of viruses via statistical gene expression analysis.

Publication ,  Journal Article
Chen, M; Carlson, D; Zaas, A; Woods, CW; Ginsburg, GS; Hero, A; Lucas, J; Carin, L
Published in: IEEE Trans Biomed Eng
March 2011

We develop a new bayesian construction of the elastic net (ENet), with variational bayesian analysis. This modeling framework is motivated by analysis of gene expression data for viruses, with a focus on H3N2 and H1N1 influenza, as well as Rhino virus and RSV (respiratory syncytial virus). Our objective is to understand the biological pathways responsible for the host response to such viruses, with the ultimate objective of developing a clinical test to distinguish subjects infected by such viruses from subjects with other symptom causes (e.g., bacteria). In addition to analyzing these new datasets, we provide a detailed analysis of the bayesian ENet and compare it to related models.

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Published In

IEEE Trans Biomed Eng

DOI

EISSN

1558-2531

Publication Date

March 2011

Volume

58

Issue

3

Start / End Page

468 / 479

Location

United States

Related Subject Headings

  • Virus Diseases
  • Rhinovirus
  • Respiratory Syncytial Viruses
  • Influenza A Virus, H3N2 Subtype
  • Influenza A Virus, H1N1 Subtype
  • Humans
  • Host-Pathogen Interactions
  • Gene Expression Profiling
  • Computational Biology
  • Biomedical Engineering
 

Citation

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Chen, M., Carlson, D., Zaas, A., Woods, C. W., Ginsburg, G. S., Hero, A., … Carin, L. (2011). Detection of viruses via statistical gene expression analysis. IEEE Trans Biomed Eng, 58(3), 468–479. https://doi.org/10.1109/TBME.2010.2059702
Chen, Minhua, David Carlson, Aimee Zaas, Christopher W. Woods, Geoffrey S. Ginsburg, Alfred Hero, Joseph Lucas, and Lawrence Carin. “Detection of viruses via statistical gene expression analysis.IEEE Trans Biomed Eng 58, no. 3 (March 2011): 468–79. https://doi.org/10.1109/TBME.2010.2059702.
Chen M, Carlson D, Zaas A, Woods CW, Ginsburg GS, Hero A, et al. Detection of viruses via statistical gene expression analysis. IEEE Trans Biomed Eng. 2011 Mar;58(3):468–79.
Chen, Minhua, et al. “Detection of viruses via statistical gene expression analysis.IEEE Trans Biomed Eng, vol. 58, no. 3, Mar. 2011, pp. 468–79. Pubmed, doi:10.1109/TBME.2010.2059702.
Chen M, Carlson D, Zaas A, Woods CW, Ginsburg GS, Hero A, Lucas J, Carin L. Detection of viruses via statistical gene expression analysis. IEEE Trans Biomed Eng. 2011 Mar;58(3):468–479.

Published In

IEEE Trans Biomed Eng

DOI

EISSN

1558-2531

Publication Date

March 2011

Volume

58

Issue

3

Start / End Page

468 / 479

Location

United States

Related Subject Headings

  • Virus Diseases
  • Rhinovirus
  • Respiratory Syncytial Viruses
  • Influenza A Virus, H3N2 Subtype
  • Influenza A Virus, H1N1 Subtype
  • Humans
  • Host-Pathogen Interactions
  • Gene Expression Profiling
  • Computational Biology
  • Biomedical Engineering